Mutiso Steve Kyende, Rono Dennis Kipkemoi, Bukachi Frederick
Department of Medical Physiology, University of Nairobi, P,O, Box 30197-00100, Nairobi, Kenya.
BMC Res Notes. 2014 Dec 18;7:931. doi: 10.1186/1756-0500-7-931.
The degree of cardiovascular function impairment parallels the degree of obesity and obese subjects have abnormal changes on the electrocardiogram (ECG). Early ECG changes in obesity have not been previously studied. The objective of the present study was to determine the early ECG changes in obese rats and their relationship with anthropometric measurements.
At seven weeks all rats in the experiment were obese and in sinus rhythm. In the experiment resting heart rate was increased (364±13 vs. 313±12 bpm, P<0.01). In contrast, the following parameters were shortened: QRS duration (77±3.6 vs. 65±2.6 ms, P<0.01); QT interval (102±5.2 vs. 88±3.7 ms, P<0.05); Q wave amplitude (-12.8±1.0 vs. -5.1±0.9 μv, P<0.01); and T wave amplitude (18.8±1.4 vs. 5.8±0.6, P<0.01). All other ECG parameters remained unchanged. With increased weight the resting heart rate (r=0.46, P<0.01) and R wave amplitude (r=0.60, P<0.01) increased.
Early in obesity there are no rhythm disturbances, but resting heart rate is increased. The QRS duration is shortened and Q and T-wave amplitudes reduced signifying ventricular changes related to impaired myocardial depolarization and repolarization. Furthermore, weight gain is correlated with an increase in heart rate and accentuation of the R wave amplitude.
心血管功能损害程度与肥胖程度平行，肥胖受试者心电图（ECG）有异常变化。肥胖早期的心电图变化此前尚未得到研究。本研究的目的是确定肥胖大鼠的早期心电图变化及其与人体测量学指标的关系。
实验至7周时，所有大鼠均肥胖且处于窦性心律。实验中静息心率增加（364±13对313±12次/分钟，P<0.01）。相比之下，以下参数缩短：QRS时限（77±3.6对65±2.6毫秒，P<0.01）；QT间期（102±5.2对88±3.7毫秒，P<0.05）；Q波振幅（-12.8±1.0对-5.1±0.9微伏，P<0.01）；以及T波振幅（18.8±1.4对5.8±0.6，P<0.01）。所有其他心电图参数保持不变。随着体重增加，静息心率（r=0.46，P<0.01）和R波振幅（r=0.60，P<0.01）增加。
肥胖早期无节律紊乱，但静息心率增加。QRS时限缩短，Q波和T波振幅降低，表明心室变化与心肌去极化和复极化受损有关。此外，体重增加与心率加快和R波振幅增大相关。
