vanVeen Kiril E B, Alblas Kees C L, Alons Imanda M E, Kerklaan Joost P, Siegersma Marry C, Wesstein Michel, Visser Leo H, Vankasteel Viviane, Jellema Korné
Department of Neurology, Medical Center Haaglanden, Postbus 432, 2501, CK, The Hague, The Netherlands.
Department of Clinical Neurophysiology, Medical Center Haaglanden, The Hague, The Netherlands.
Muscle Nerve. 2015 Sep;52(3):380-5. doi: 10.1002/mus.24551. Epub 2015 Jun 18.
We conducted a randomized, double-blind, placebo-controlled trial to evaluate the effect of ultrasound-guided corticosteroid injection in patients with ulnar neuropathy at the elbow (UNE).
Fifty-five patients were randomized between an ultrasound-guided injection of 1 ml containing 40 mg methylprednisolone acetate and 10 mg lidocaine hydrochloride or a placebo injection. The primary outcome was the subjective change of symptoms after 3 months. The secondary outcomes were change in electrodiagnostic studies and ultrasonography findings.
A success rate of 30% was found in the corticosteroid injection group versus 28% in the placebo injection group. Only the nerve cross-sectional area changed significantly in the intervention group, from a mean of 11.9 mm(2) to 10.9 mm(2) .
We could not demonstrate a positive effect of ultrasound-guided corticosteroid injection in UNE compared with placebo. Favorable outcomes may be attributed to the natural course of UNE or the effect of patient education.
我们进行了一项随机、双盲、安慰剂对照试验，以评估超声引导下皮质类固醇注射对肘部尺神经病变（UNE）患者的疗效。
55例患者被随机分为两组，一组接受超声引导下注射1毫升含40毫克醋酸甲泼尼龙和10毫克盐酸利多卡因的溶液，另一组接受安慰剂注射。主要结局是3个月后症状的主观变化。次要结局是电诊断研究和超声检查结果的变化。
皮质类固醇注射组的成功率为30%，而安慰剂注射组为28%。仅干预组的神经横截面积有显著变化，从平均11.9平方毫米降至10.9平方毫米。
与安慰剂相比，我们未能证明超声引导下皮质类固醇注射对UNE有积极效果。良好的结局可能归因于UNE的自然病程或患者教育的作用。
