Hatipoglu Esra, Topsakal Nuri, Erkut Atilgan Oya, Camliguney Asiye Filiz, Ikitimur Baris, Ugurlu Serdal, Niyazoglu Mutlu, Cotuk Hasan Birol, Kadioglu Pinar
Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
Marmara University School of Physical Education and Sports, Istanbul, Turkey.
Clin Endocrinol (Oxf). 2015 Jul;83(1):91-7. doi: 10.1111/cen.12708. Epub 2015 Feb 6.
Impaired physical performance is a disturbing complication of acromegaly. We aimed to evaluate the role of regular exercise in amelioration of the impaired physical performance in acromegaly.
Patients with acromegaly were divided into two groups according to their participation in a prescheduled programme of exercise. Participants in the study group were exercised 3 days a week for 3 consecutive months. Exercise tolerance was evaluated by maximal oxygen consumption (VO2 max) and time (T) taken to complete the Bruce protocol, muscle flexibility by the sit and reach test (SRT) and muscle strength by the hand grip strength test (HGST). Concomitantly, anthropometric assessment was performed using body mass index (BMI), waist-to-hip ratio (WHR), skinfold measurements from 8 points, percentage body fat (PBF), fat mass (FM) and lean body mass (LBM).
After 3 months of exercise, VO2 max and T were higher in cases that exercised than in cases that did not (P = 0.004 and P = 0.001). Over 3 months, within the exercise group, VO2 max and T of the Bruce protocol increased (P = 0.003 and P = 0.004) and heart rate during warming decreased (P = 0.04). SRT increased within the exercise group after 3 months (P = 0.004). HGSRT did not change significantly (right P = 0.06 and left P = 0.2). The sum of skinfolds, BMI, WHR and LBM remained stable over the study period (P = 0.1, P = 0.08, P = 0.3 and P = 0.09). PBF decreased slightly and FM decreased significantly over 3 months (P = 0.05 and P = 0.03).
Even short-term exercise may improve impaired physical performance, muscle activity and disturbed body fat composition in acromegaly.
身体机能受损是肢端肥大症令人困扰的并发症。我们旨在评估规律运动对改善肢端肥大症患者受损身体机能的作用。
根据肢端肥大症患者是否参与预定的运动计划将其分为两组。研究组参与者每周锻炼3天，持续3个月。通过最大耗氧量（VO2 max）和完成布鲁斯运动试验所需时间（T）评估运动耐力，通过坐立前屈试验（SRT）评估肌肉柔韧性，通过握力测试（HGST）评估肌肉力量。同时，使用体重指数（BMI）、腰臀比（WHR）、8点皮褶测量、体脂百分比（PBF）、脂肪量（FM）和去脂体重（LBM）进行人体测量评估。
运动3个月后，运动组的VO2 max和T高于未运动组（P = 0.004和P = 0.001）。在3个月内，运动组中布鲁斯运动试验的VO2 max和T增加（P = 0.003和P = 0.004），热身时心率下降（P = 0.04）。3个月后运动组的SRT增加（P = 0.004）。HGST无显著变化（右侧P = 0.06，左侧P = 0.2）。在研究期间，皮褶总和、BMI、WHR和LBM保持稳定（P = 0.1、P = 0.08、P = 0.3和P = 0.09）。3个月内PBF略有下降，FM显著下降（P = 0.05和P = 0.03）。
即使是短期运动也可能改善肢端肥大症患者受损的身体机能、肌肉活动和紊乱的身体脂肪组成。
