Azouvi Philippe, Vallat-Azouvi Claire, Millox Valérie, Darnoux Emmanuelle, Ghout Idir, Azerad Sylvie, Ruet Alexis, Bayen Eleonore, Pradat-Diehl Pascale, Aegerter Philippe, Weiss Jean-Jacques, Jourdan Claire
a AP-HP, Service de Médecine Physique et de Réadaptation , Hôpital Raymond Poincaré , Garches , France.
Neuropsychol Rehabil. 2015;25(6):864-78. doi: 10.1080/09602011.2014.990907. Epub 2014 Dec 18.
The Dysexecutive Questionnaire (DEX; Wilson, Pettigrew, & Teasdale, 1998 ) has been designed to assess executive dysfunctions in daily life. However, its relationships with cognitive testing, mood, and the ability to fulfil daily life demands, have not yet been systematically addressed. The objective of this study was to address these issues in a prospective four-year follow-up study of patients with severe traumatic brain injury (TBI) (PariS-TBI study). One hundred and forty seven patients were included. The DEX (self-version) showed a good internal consistency. The total DEX score was significantly inversely correlated with years of education, but did not significantly correlate with any initial injury severity measure. The DEX was significantly and positively related to cognitive deficits, as assessed with the Neurobehavioral Rating Scale-Revised (NRS-R); with mood disorders, as assessed with the Hospital Anxiety and Depression Scale (HADS); with dependency in elementary and extended activities of daily living; and with non-return to work. In multivariate analyses, cognitive and mood impairments were significantly and independently related to the total DEX score. These results suggest that the DEX is a multidetermined sensitive questionnaire to detect everyday life difficulties in patients with severe TBI at a chronic stage.
执行功能障碍问卷(DEX;Wilson、Pettigrew和Teasdale,1998年)旨在评估日常生活中的执行功能障碍。然而,它与认知测试、情绪以及满足日常生活需求能力之间的关系尚未得到系统研究。本研究的目的是在一项针对重度创伤性脑损伤(TBI)患者的前瞻性四年随访研究(巴黎TBI研究)中解决这些问题。纳入了147名患者。DEX(自评版)显示出良好的内部一致性。DEX总分与受教育年限显著负相关,但与任何初始损伤严重程度指标均无显著相关性。DEX与经修订的神经行为评定量表(NRS-R)评估的认知缺陷、与医院焦虑抑郁量表(HADS)评估的情绪障碍、与基本和扩展日常生活活动中的依赖程度以及与未重返工作显著正相关。在多变量分析中,认知和情绪障碍与DEX总分显著且独立相关。这些结果表明,DEX是一个多因素敏感问卷,可用于检测重度TBI患者慢性期的日常生活困难。