[Features of the modulation of afferent reactions by agonists and antagonists of opiate receptors and competitive stimulation of the skin under conditions of changing barometric pressure].

Afferent body reactions were studied under conditions of changes of atmospheric pressure in electrostimulation of skin zones and use of various agonists and antagonists of opiate receptors. The results suggest maintenance of a sufficiently high therapeutic efficacy of transcutaneous electrostimulation at levels of up to 5.5 km above sea level and emphasize the leading role of endogenous ligands of opiate receptors in realization of the analgesic effects of competitive skin stimulation. The results of the study also provide evidence of a high analgesic activity of dalargin, a synthetic analogue of leu-enkephalin, which persisted at a height of up to 7.5 km above sea level. Increasing the resistance of the experimental animals to acute high-altitude hypoxia, this agent facilitates the development of analgesic reactions in electrostimulation of the skin.