Capozzella A, Gioffrè P A, Chighine A, Sacco C, Casale T, Scala B, Palatiello A, Pimpinella B, Tomei F, Rosati M V
Department of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine, Sapienza University of Rome, Italy.
Ann Ig. 2014 Nov-Dec;26(6):537-46. doi: 10.7416/ai.2014.2012.
The aim of this pilot study is to evaluate whether occupational exposure to low doses of pollutants present in the air of the city selected for the study could cause alterations in the concentration of atrial natriuretic peptide (ANP) in workers from the Municipal Police with outdoor tasks, compared to those with indoor tasks.
A total of 208 non-smoking male and female subjects were enrolled and divided on the basis of whether their tasks were mainly outdoors or indoors. The dosage of plasma ANP was carried out on all workers included in the study. Differences between means and frequencies were compared using student's t-test for unpaired data and chi-square test with Yates' correction, and they were considered significant when the p value was <0.05.
Even after the subdivision of the total sample on the basis of sex, mean plasma levels of ANP were higher but not statistically significant in traffic police compared with controls.
The preliminary results suggest that further studies should be conducted before the influence of urban pollution on ANP could be confirmed or rejected.
本初步研究旨在评估，与从事室内任务的市警察相比，从事室外任务的市警察职业性接触所选研究城市空气中低剂量污染物是否会导致心房利钠肽（ANP）浓度改变。
共招募了208名不吸烟的男性和女性受试者，并根据其任务主要是在室外还是室内进行分组。对研究中的所有工人进行血浆ANP剂量测定。使用学生t检验（用于非配对数据）和经Yates校正的卡方检验比较均值和频率之间的差异，当p值<0.05时，差异被认为具有统计学意义。
即使在根据性别对总样本进行细分之后，与对照组相比，交警的血浆ANP平均水平更高，但无统计学意义。
初步结果表明，在确认或否定城市污染对ANP的影响之前，应进行进一步研究。
