Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel,
Arch Gynecol Obstet. 2015 Jun;291(6):1199-203. doi: 10.1007/s00404-014-3597-6. Epub 2014 Dec 19.
To present a case of very late (more than 20 years) recurrence of epithelial ovarian carcinoma and to review the pertinent literature. We encountered a 50-year-old patient who, at the age of 22, underwent cytoreductive surgery and adjuvant chemotherapy for stage III serous ovarian carcinoma. She recurred after 28 years and underwent secondary surgery and chemotherapy.
A PubMed search of the English literature containing the following key words: ovarian cancer, late recurrence, late relapse, late metastasis was performed.
Only five cases (including the present one) with recurrence after more than 20 years are so far on record. Of these, four patients were 33 years old or younger and had advanced stage at diagnosis. Time to recurrence ranged from 21 to 28 years. All patients had serous carcinoma and three had recurrence in lymph nodes.
Very late recurrence is an extremely rare event and may result from either regrowth of dormant tumor cells or from development of a new cancer. Lifelong follow-up is critically important for ovarian cancer patients.
报告一例上皮性卵巢癌非常晚期（20 年以上）复发病例，并复习相关文献。我们遇到一位 50 岁患者，22 岁时因 III 期浆液性卵巢癌行肿瘤细胞减灭术和辅助化疗。28 年后复发，行二次手术和化疗。
在 PubMed 上进行英文文献检索，包含以下关键词：卵巢癌、晚期复发、晚期复发、晚期转移。
目前为止仅记录到 5 例（包括本病例）超过 20 年的复发。其中 4 例患者年龄在 33 岁或以下，且诊断时为晚期。复发时间为 21 至 28 年。所有患者均为浆液性癌，3 例有淋巴结复发。
非常晚期复发是一种极其罕见的事件，可能是休眠肿瘤细胞的再生长或新癌症的发展所致。对于卵巢癌患者，终生随访至关重要。
