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13例犬口腔鳞状细胞癌中增殖细胞核抗原(PCNA)与分级:与预后的关联

PCNA and grade in 13 canine oral squamous cell carcinomas: association with prognosis.

作者信息

Mestrinho L A, Faísca P, Peleteiro M C, Niza M M R E

机构信息

CIISA, Faculdade de Medicina Veterinária, ULisboa, Avenida da Universidade Técnica, 1300-477, Lisboa, Portugal.

CBIOS, Universidade Lusófona de Humanidade e Tecnologias, Campo Grande, 376, 1749-024, Lisboa, Portugal.

出版信息

Vet Comp Oncol. 2017 Mar;15(1):18-24. doi: 10.1111/vco.12134. Epub 2014 Dec 18.

Abstract

This study evaluated the prognosis factors of age, tumour size, anatomic location, histological grade and proliferating cell nuclear antigen (PCNA) expression in 13 dogs with oral squamous cell carcinoma (OSCC) with bone invasion and without signs of lymph node or distant metastasis. All animals were treated with radical excision performed with at least 1 cm margin, based on computed tomography images. In the 2-year follow-up, median disease-free survival was 138 days for dogs with grade 3 tumours and was not reached for those with grade 2 tumours. Grade 3 tumours and PCNA labelling index ≥65% were related with a shorter disease-free survival time and consequently poor prognosis (p = 0.003 and p = 0.034, respectively). Mean PCNA labelling index was significantly higher in recurrent cases (p = 0.011). Histological grade and PCNA expression may be important prognosis factors in canine OSCC.

摘要

本研究评估了13只患有口腔鳞状细胞癌(OSCC)且伴有骨侵袭、无淋巴结或远处转移迹象的犬的年龄、肿瘤大小、解剖位置、组织学分级和增殖细胞核抗原(PCNA)表达等预后因素。所有动物均根据计算机断层扫描图像进行至少1厘米切缘的根治性切除。在2年的随访中,3级肿瘤犬的无病生存期中位数为138天,2级肿瘤犬未达到该数值。3级肿瘤和PCNA标记指数≥65%与较短的无病生存时间相关,因此预后较差(分别为p = 0.003和p = 0.034)。复发病例的平均PCNA标记指数显著更高(p = 0.011)。组织学分级和PCNA表达可能是犬OSCC的重要预后因素。

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