增殖细胞核抗原在犬皮肤基底细胞癌和鳞状细胞癌中的表达：与有丝分裂指数及组织学特征的相关性

Expression of proliferating cell nuclear antigen in basal cell carcinomas and in squamous cell carcinomas of canine skin: correlation with mitotic index and histological features.

作者信息

Maiolino P, Restucci B, De Vico G

机构信息

Dipartimento di Patologia, Profilassi e di Ispezione degli Alimenti, Facoltà di Medicina Veterinaria, Università degli studi di Napoli Federico II, Italy.

出版信息

Zentralbl Veterinarmed A. 1995 Jul;42(5):339-43. doi: 10.1111/j.1439-0442.1995.tb00385.x.

DOI:10.1111/j.1439-0442.1995.tb00385.x

PMID:8578908

Abstract

In this study we evaluated the behaviour of proliferating cell nuclear antigen labelling index (PCNA-LI), mitotic index (MI) and histological features in ten basal cell carcinomas (BCC) and ten squamous cell carcinomas (SCC) of canine skin. PCNA-LI ranged from 2.1% to 4.8% in SCC and from 0.1% to 2.0% in BCC samples. A significant statistical correlation, between PCNA-LI and MI could be demonstrated only in SCC, but not in BCC samples. Furthermore, PCNA-LI was also significantly and consistently greater in the three BCC of solid type and in poorly differentiated SCC. PCNA-LI may provide additional criterion in evaluating the intrinsic malignancy and growth potential of the above tumours.

摘要

在本研究中，我们评估了犬皮肤的10例基底细胞癌（BCC）和10例鳞状细胞癌（SCC）中增殖细胞核抗原标记指数（PCNA-LI）、有丝分裂指数（MI）的表现及组织学特征。SCC样本中PCNA-LI范围为2.1%至4.8%，BCC样本中为0.1%至2.0%。仅在SCC中可证明PCNA-LI与MI之间存在显著的统计学相关性，而在BCC样本中未发现。此外，实性型的3例BCC和低分化SCC中的PCNA-LI也显著且持续更高。PCNA-LI可能为评估上述肿瘤的内在恶性程度和生长潜力提供额外标准。