King Thomas, McKenna John, Alexandroff Anton B
Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK.
Patient Prefer Adherence. 2014 Nov 25;8:1629-34. doi: 10.2147/PPA.S38830. eCollection 2014.
Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic acid and pan-retinoic acid agonist, is a new and effective systemic treatment for chronic hand eczema, which provides another treatment option. A "clear" or "almost clear" response can be achieved in up to half of patients within a 24-week course of treatment. Even higher rates of remission can be obtained with a longer duration of treatment. Alitretinoin has a favorable overall profile of adverse effects; however, female patients who are at risk of becoming pregnant should follow a strict pregnancy-prevention program due to the teratogenic effects of this drug.
慢性手部湿疹是一种常见且往往使人衰弱的病症。阿利维A酸，一种9-顺式视黄酸和泛视黄酸激动剂，是一种治疗慢性手部湿疹的新型有效全身治疗药物，它提供了另一种治疗选择。在24周的治疗疗程中，高达一半的患者可实现“清除”或“几乎清除”的反应。治疗时间延长可获得更高的缓解率。阿利维A酸的总体不良反应情况良好；然而，由于该药物的致畸作用，有怀孕风险的女性患者应遵循严格的预防怀孕方案。
