阿利维A酸治疗重度慢性手部湿疹。
Alitretinoin for the treatment of severe chronic hand eczema.
作者信息
King Thomas, McKenna John, Alexandroff Anton B
机构信息
Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK.
出版信息
Patient Prefer Adherence. 2014 Nov 25;8:1629-34. doi: 10.2147/PPA.S38830. eCollection 2014.
Abstract
Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic acid and pan-retinoic acid agonist, is a new and effective systemic treatment for chronic hand eczema, which provides another treatment option. A "clear" or "almost clear" response can be achieved in up to half of patients within a 24-week course of treatment. Even higher rates of remission can be obtained with a longer duration of treatment. Alitretinoin has a favorable overall profile of adverse effects; however, female patients who are at risk of becoming pregnant should follow a strict pregnancy-prevention program due to the teratogenic effects of this drug.
摘要
慢性手部湿疹是一种常见且往往使人衰弱的病症。阿利维A酸，一种9-顺式视黄酸和泛视黄酸激动剂，是一种治疗慢性手部湿疹的新型有效全身治疗药物，它提供了另一种治疗选择。在24周的治疗疗程中，高达一半的患者可实现“清除”或“几乎清除”的反应。治疗时间延长可获得更高的缓解率。阿利维A酸的总体不良反应情况良好；然而，由于该药物的致畸作用，有怀孕风险的女性患者应遵循严格的预防怀孕方案。
相似文献
1
Alitretinoin for the treatment of severe chronic hand eczema.阿利维A酸治疗重度慢性手部湿疹。
Patient Prefer Adherence. 2014 Nov 25;8:1629-34. doi: 10.2147/PPA.S38830. eCollection 2014.
2
Alitretinoin: A Review in Severe Chronic Hand Eczema.阿利特罗汀：严重慢性手部湿疹的综述。
Drugs. 2016 Sep;76(13):1271-1279. doi: 10.1007/s40265-016-0621-0.
3
Alitretinoin: in severe chronic hand eczema.阿利维A酸：用于重度慢性手部湿疹。
Drugs. 2009 Aug 20;69(12):1625-34. doi: 10.2165/11202200-000000000-00000.
4
Alitretinoin: An Update of Real-World Evidence in The Management of Chronic Hand Dermatitis.阿利维A酸：慢性手部皮炎管理的真实世界证据更新
Skin Therapy Lett. 2018 Jul;23(4):1-4.
5
Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema.阿利维 A 酸治疗复发慢性手部湿疹的成功再治疗。
Br J Dermatol. 2010 Feb 1;162(2):420-6. doi: 10.1111/j.1365-2133.2009.09572.x. Epub 2009 Nov 10.
6
Update on the use of alitretinoin in treating chronic hand eczema.阿利维 A 酸治疗慢性手部湿疹的应用进展。
Clin Cosmet Investig Dermatol. 2010 Apr 19;3:59-65. doi: 10.2147/ccid.s6495.
7
Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial.口服阿利维A酸（9-顺式维甲酸）治疗对局部用皮质类固醇难治的重度慢性手部湿疹患者的疗效与安全性：一项随机、双盲、安慰剂对照、多中心试验的结果
Br J Dermatol. 2008 Apr;158(4):808-17. doi: 10.1111/j.1365-2133.2008.08487.x. Epub 2008 Feb 21.
8
[Alitretinoin (Toctino): A French follow-up study of harmacovigilance].[阿利维A酸（Toctino）：法国药物警戒随访研究]
Therapie. 2019 Oct;74(5):513-519. doi: 10.1016/j.therap.2019.02.006. Epub 2019 Mar 31.
9
[Response to treatment with oral alitretinoin in patients with chronic hand eczema that is refractory to treatment with potent topical corticosteroids: experience in 15 patients].[口服阿利维A酸治疗对强效外用糖皮质激素治疗无效的慢性手部湿疹患者的疗效：15例患者的经验]
Actas Dermosifiliogr. 2011 Oct;102(8):616-22. doi: 10.1016/j.ad.2010.10.012. Epub 2011 Feb 26.
10
Alitretinoin in Dermatology-An Update.阿利维A酸在皮肤科的应用——最新进展
Indian J Dermatol. 2015 Sep-Oct;60(5):520. doi: 10.4103/0019-5154.164426.
引用本文的文献
1
Italian Expert Opinion on Chronic Hand Eczema: from Guidelines to Clinical Practice.意大利慢性手部湿疹专家意见：从指南到临床实践
Dermatol Ther (Heidelb). 2025 Jan;15(1):75-93. doi: 10.1007/s13555-024-01312-y. Epub 2024 Nov 28.
2
A Review of Existing and New Treatments for the Management of Hand Eczema.手部湿疹治疗的现有和新疗法综述。
J Cutan Med Surg. 2023 Sep-Oct;27(5):493-503. doi: 10.1177/12034754231188325. Epub 2023 Jul 27.
3
Efficacy and Safety of Alitretinoin Therapy in Korean Elderly Patients with Chronic Hand Eczema: A Retrospective Single Center Study.阿利维A酸治疗韩国老年慢性手部湿疹患者的疗效与安全性：一项回顾性单中心研究
Ann Dermatol. 2019 Dec;31(6):595-600. doi: 10.5021/ad.2019.31.6.595. Epub 2019 Oct 31.
4
Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges.治疗慢性手部湿疹的药物：成就与关键挑战
Ther Clin Risk Manag. 2020 Dec 31;16:1319-1332. doi: 10.2147/TCRM.S292504. eCollection 2020.
5
Efficacy of Pumpkin Ointment in Treatment of Chronic Hand Eczema: A Randomized, Active-Controlled, Double Blind Clinical Trial.南瓜软膏治疗慢性手部湿疹的疗效：一项随机、活性对照、双盲临床试验
Iran J Public Health. 2020 Jul;49(7):1339-1347. doi: 10.18502/ijph.v49i7.3588.
6
The effectiveness of alitretinoin for the treatment of chronic hand eczema: A meta-analysis.阿利维A酸治疗慢性手部湿疹的有效性：一项荟萃分析。
Int J Health Sci (Qassim). 2018 Mar-Apr;12(2):70-79.
7
Review of Medicinal Remedies on Hand Eczema Based on Iranian Traditional Medicine: A Narrative Review Article.基于伊朗传统医学的手部湿疹药物疗法综述：一篇叙述性综述文章。
Iran J Public Health. 2016 Aug;45(8):986-996.
8
Alitretinoin in Dermatology-An Update.阿利维A酸在皮肤科的应用——最新进展
Indian J Dermatol. 2015 Sep-Oct;60(5):520. doi: 10.4103/0019-5154.164426.
本文引用的文献
1
The European Standard Series and its additions: are they of any use in 2013?欧洲标准系列及其增补内容：在2013年它们还有用吗？
Eur J Dermatol. 2014 Jan-Feb;24(1):15-22. doi: 10.1684/ejd.2013.2258.
2
Oral, esophageal and cutaneous lichen ruber planus controlled with alitretinoin: case report and review of the literature.阿利维 A 酸治疗口腔、食管和皮肤扁平苔藓：病例报告及文献复习。
Dermatology. 2013;226(4):302-10. doi: 10.1159/000349980. Epub 2013 Aug 15.
3
Successful therapy of refractory Hailey-Hailey disease with oral alitretinoin.口服阿利维A酸成功治疗难治性黑利-黑利病。
Br J Dermatol. 2014 Jan;170(1):209-11. doi: 10.1111/bjd.12582.
4
Successful treatment of atypical adult pityriasis rubra pilaris with oral alitretinoin.口服阿利维A酸成功治疗非典型成人毛发红糠疹。
J Am Acad Dermatol. 2013 Aug;69(2):e105-6. doi: 10.1016/j.jaad.2013.01.036.
5
Treatment of Darier disease with oral alitretinoin.口服阿利维 A 酸治疗大疱性表皮松解症。
Clin Exp Dermatol. 2013 Jul;38(5):523-5. doi: 10.1111/ced.12078.
6
Successful treatment with oral alitretinoin in women of childbearing potential with Darier's disease.口服阿利维A酸成功治疗有生育潜力的患有毛囊角化病的女性。
Br J Dermatol. 2013 Sep;169(3):709-10. doi: 10.1111/bjd.12348.
7
Complete remission of alopecia areata under treatment of chronic hand eczema with alitretinoin.在使用阿利维A酸治疗慢性手部湿疹的过程中斑秃完全缓解。
Eur J Dermatol. 2013 Jan-Feb;23(1):110-1. doi: 10.1684/ejd.2012.1913.
8
American contact dermatitis society core allergen series.美国接触性皮炎学会核心过敏原系列。
Dermatitis. 2013 Jan-Feb;24(1):7-9. doi: 10.1097/DER.0b013e318281d87b.
9
Treatment of 2 patients with mycosis fungoides with alitretinoin.用阿利维A酸治疗2例蕈样肉芽肿患者。
J Am Acad Dermatol. 2012 Dec;67(6):e265-7. doi: 10.1016/j.jaad.2012.05.011.
10
Successful treatment with alitretinoin of dissecting cellulitis of the scalp in keratitis-ichthyosis-deafness syndrome.阿利维A酸成功治疗角膜炎-鱼鳞病-耳聋综合征头皮部穿掘性蜂窝织炎。
Acta Derm Venereol. 2013 Jul 6;93(4):473-4. doi: 10.2340/00015555-1499.
Zotero 插件