Khademi Alemeh, Mansuri Parvin, Pahlevan Daryoush, Bozorgi Mahbubeh, Nasiri Malihe, Hejazi Somayeh, Azizian Zahra, Shirbeigi Laila
Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2020 Jul;49(7):1339-1347. doi: 10.18502/ijph.v49i7.3588.
Hand Eczema (HE) is chronic skin disease with a high prevalence in population. It has negative impact on the quality of life. Due to the public interest in herbal remedies, we attempt to assess the efficacy of pumpkin ointment in treatment of chronic HE in this research.
This study was conducted in an outpatient clinic at Imam-Khomeini Hospital in Tehran (Iran) from May 2015 to Nov 2016. We performed a double-blind trial on 60 patients with chronic HE randomized to four groups included pumpkin, betamethasone, eucerin and almond ointment (n=15 for each group) for 28 days. Patients were ordered to apply ointments twice a day. Hand Eczema Severity Index (HECSI) and Dermatology Life Quality Index (DLQI) of the patients were evaluated by a dermatologist on the 1st, 14th and 28th d after the start of treatment.
Patients' DLQI scores in pumpkin and betamethasone group was significant and pumpkin group showed a better response in quality of life (=0.001). Betamethasone and pumpkin ointment were effective and showed significant improvement compared with almond and eucerin and reduce HECSI scores (=0.002 and =0.012 respectively). Betamethasone ointment outcome on HECSI scores in comparison with topical pumpkin was significant (<0.001). No clinically adverse effects were observed.
Although pumpkin ointment showed a better response in patients' DLQI in HE but it was less effective than betamethasone in decreasing HECSI.
手部湿疹（HE）是一种在人群中患病率较高的慢性皮肤病。它对生活质量有负面影响。由于公众对草药疗法的关注，我们试图在本研究中评估南瓜软膏治疗慢性手部湿疹的疗效。
本研究于2015年5月至2016年11月在德黑兰伊玛目霍梅尼医院的门诊进行。我们对60例慢性手部湿疹患者进行了双盲试验，将他们随机分为四组，分别使用南瓜软膏、倍他米松、优色林和杏仁软膏（每组15例），为期28天。患者被要求每天涂抹两次软膏。在治疗开始后的第1天、第14天和第28天，由皮肤科医生评估患者的手部湿疹严重程度指数（HECSI）和皮肤病生活质量指数（DLQI）。
南瓜组和倍他米松组患者的DLQI评分有显著差异，南瓜组在生活质量方面显示出更好的反应（P = 0.001）。倍他米松和南瓜软膏有效，与杏仁和优色林相比有显著改善，并降低了HECSI评分（分别为P = 0.002和P = 0.012）。与局部使用南瓜相比，倍他米松软膏对HECSI评分的效果显著（P < 0.001）。未观察到临床不良反应。
虽然南瓜软膏在手部湿疹患者的DLQI方面显示出更好的反应，但在降低HECSI方面不如倍他米松有效。
