一种将吲哚转化为吲哚醌的方法。
A procedure for transforming indoles into indolequinones.
作者信息
Eastabrook Andrew S, Wang Christy, Davison Emma K, Sperry Jonathan
机构信息
School of Chemical Sciences, University of Auckland , 23 Symonds Street, Auckland, New Zealand.
出版信息
J Org Chem. 2015 Jan 16;80(2):1006-17. doi: 10.1021/jo502509s. Epub 2015 Jan 6.
PMID:25525818
Abstract
A procedure that converts a series of structurally diverse, readily available indole derivatives to their corresponding indolequinones is described. The three-step route commences with an iridium catalyzed C-H borylation to give a 7-borylindole that upon oxidation-hydrolysis affords the 7-hydroxyindole. Subsequent oxidation provides the indolequinone.
摘要
描述了一种将一系列结构多样、易于获得的吲哚衍生物转化为其相应吲哚醌的方法。该三步路线始于铱催化的C-H硼化反应，生成7-硼基吲哚，经氧化水解得到7-羟基吲哚。随后的氧化反应生成吲哚醌。
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