Loschi Michael, Porcher Raphael, Peffault de Latour Regis, Vanneaux Valerie, Robin Marie, Xhaard Alienor, Sicre de Fontebrune Flore, Larghero Jerome, Socie Gerard
Centre Henri Becquerel, Hematology, Rouen, France; AP-HP, Saint-Louis Hospital, Hematology - Transplantation, Paris, France.
AP-HP, Hotel-Dieu Hospital, Statistics, Paris, France.
Biol Blood Marrow Transplant. 2015 Mar;21(3):569-74. doi: 10.1016/j.bbmt.2014.12.009. Epub 2014 Dec 17.
The pathophysiology of acute graft-versus-host disease (GVHD) remains poorly understood in humans. Although T cell subsets have been identified to play a major role in disease initiation in rodents, clinical data on the effect of these different subsets are scarce and conflicting. To address this question, immunophenotyping analyses were performed on the graft in 210 patients. The onset of acute GVHD was retrospectively correlated with these subpopulations. In an adjusted analysis, only the absolute count of CD45lo/CD62Llo CD8(+) T cells (effector memory T cells) was significantly associated with the onset of grade 2 to 4 acute GVHD. Thus, in contrast to experimental data, we found that the number of effector memory but not of naïve T cells was associated with the onset of GVHD. These results should be kept in mind while clinical trials, which aim to deplete naïve T cells, are underway in several institutions.
人类急性移植物抗宿主病（GVHD）的病理生理学仍未被充分理解。尽管已确定T细胞亚群在啮齿动物疾病起始中起主要作用，但关于这些不同亚群作用的临床数据却很少且相互矛盾。为解决这个问题，对210例患者的移植物进行了免疫表型分析。急性GVHD的发病与这些亚群进行了回顾性关联分析。在一项校正分析中，只有CD45lo/CD62Llo CD8(+) T细胞（效应记忆T细胞）的绝对计数与2至4级急性GVHD的发病显著相关。因此，与实验数据相反，我们发现效应记忆T细胞而非初始T细胞的数量与GVHD的发病有关。在几个机构正在进行旨在清除初始T细胞的临床试验时，应牢记这些结果。
