Bush L M, Boscia J A, Wendeler M, Pitsakis P G, Kaye D
Division of Infectious Diseases, Medical College of Pennsylvania, Philadelphia 19129.
Antimicrob Agents Chemother. 1989 Aug;33(8):1198-200. doi: 10.1128/AAC.33.8.1198.
The suppression of bacterial growth that persists after brief exposure to antimicrobial agents has been termed the postantibiotic effect (PAE). This pharmacodynamic interaction varies for each microorganism-antimicrobial agent combination. Daptomycin (LY146032) is a new lipopeptide antibiotic with activity against gram-positive organisms. We studied the in vitro bactericidal activities and PAEs of the following drugs: daptomycin compared with penicillin G and vancomycin, without and with gentamicin against Enterococcus faecalis strains; daptomycin compared with nafcillin and vancomycin against methicillin-susceptible Staphylococcus aureus strains; and daptomycin compared with vancomycin against methicillin-resistant S. aureus strains. Daptomycin, alone and when used in combination with gentamicin, exhibited greater bactericidal activity and in general produced a longer PAE than standard effective regimens against the organism strains studied.
短暂接触抗菌药物后持续存在的细菌生长抑制现象被称为抗生素后效应（PAE）。这种药效学相互作用因每种微生物 - 抗菌药物组合而异。达托霉素（LY146032）是一种对革兰氏阳性菌有活性的新型脂肽类抗生素。我们研究了以下药物的体外杀菌活性和PAE：达托霉素与青霉素G和万古霉素比较，在有无庆大霉素的情况下对粪肠球菌菌株的作用；达托霉素与萘夫西林和万古霉素比较对甲氧西林敏感金黄色葡萄球菌菌株的作用；以及达托霉素与万古霉素比较对耐甲氧西林金黄色葡萄球菌菌株的作用。达托霉素单独使用以及与庆大霉素联合使用时，与针对所研究菌株的标准有效方案相比，表现出更强的杀菌活性，并且总体上产生更长的PAE。
