达托霉素对14株葡萄球菌和肺炎球菌临床分离株的抗生素后效应
Postantibiotic effects of daptomycin against 14 staphylococcal and pneumococcal clinical isolates.
作者信息
Pankuch G A, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
出版信息
Antimicrob Agents Chemother. 2003 Sep;47(9):3012-4. doi: 10.1128/AAC.47.9.3012-3014.2003.
Abstract
Daptomycin mean staphylococcal postantibiotic effects (PAEs) were 1.1 to 6.2 h, with a mean of 2.5 h. The mean pneumococcal PAEs were 1.7 h, ranging between 1.0 and 2.5 h. The staphylococcal and pneumococcal postantibiotic sub-MIC effects at 0.4 times the MIC ranged from 3.0 to >12.0 h and 1.9 to >12.0 h, respectively.
摘要
达托霉素对葡萄球菌的平均抗生素后效应（PAEs）为1.1至6.2小时，平均为2.5小时。肺炎球菌的平均PAEs为1.7小时，范围在1.0至2.5小时之间。在0.4倍MIC时，葡萄球菌和肺炎球菌的抗生素后亚MIC效应分别为3.0至>12.0小时和1.9至>12.0小时。
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