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达托霉素对14株葡萄球菌和肺炎球菌临床分离株的抗生素后效应

Postantibiotic effects of daptomycin against 14 staphylococcal and pneumococcal clinical isolates.

作者信息

Pankuch G A, Jacobs M R, Appelbaum P C

机构信息

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA.

出版信息

Antimicrob Agents Chemother. 2003 Sep;47(9):3012-4. doi: 10.1128/AAC.47.9.3012-3014.2003.

DOI:10.1128/AAC.47.9.3012-3014.2003
PMID:12937016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC182610/
Abstract

Daptomycin mean staphylococcal postantibiotic effects (PAEs) were 1.1 to 6.2 h, with a mean of 2.5 h. The mean pneumococcal PAEs were 1.7 h, ranging between 1.0 and 2.5 h. The staphylococcal and pneumococcal postantibiotic sub-MIC effects at 0.4 times the MIC ranged from 3.0 to >12.0 h and 1.9 to >12.0 h, respectively.

摘要

达托霉素对葡萄球菌的平均抗生素后效应（PAEs）为1.1至6.2小时，平均为2.5小时。肺炎球菌的平均PAEs为1.7小时，范围在1.0至2.5小时之间。在0.4倍MIC时，葡萄球菌和肺炎球菌的抗生素后亚MIC效应分别为3.0至>12.0小时和1.9至>12.0小时。

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Antimicrob Agents Chemother. 2002 Aug;46(8):2595-601. doi: 10.1128/AAC.46.8.2595-2601.2002.
2
In vitro bactericidal activity of daptomycin against staphylococci.达托霉素对葡萄球菌的体外杀菌活性。
J Antimicrob Chemother. 2002 Mar;49(3):467-70. doi: 10.1093/jac/49.3.467.
3
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7
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8
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J Antimicrob Chemother. 1993 Jun;31(6):881-92. doi: 10.1093/jac/31.6.881.
10
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J Antimicrob Chemother. 1993 Oct;32(4):519-37. doi: 10.1093/jac/32.4.519.