Mouton R P, Mulders S L
Department of Medical Microbiology, University Hospital Leiden, The Netherlands.
J Antimicrob Chemother. 1987 Oct;20(4):513-7. doi: 10.1093/jac/20.4.513.
LY146032, a new lipopeptide antibiotic, was compared with vancomycin, teicoplanin, cefamandole and ciprofloxacin, against 107 clinical isolates comprising methicillin-susceptible and methicillin-resistant Staphylococcus spp., Streptococcus faecalis and Corynebacterium spp. All staphylococci were susceptible to all agents, except that some of the methicillin-resistant strains were resistant to cefamandole. Only LY146032 and ciprofloxacin were bactericidal to Str. faecalis. Development of resistance was studied by serial transfers of ten selected strains. A stable greater than or equal to eight-fold increase of the MIC over the breakpoint was found to develop to a variable extent against all agents tested. Simultaneous development of resistance to any of the other antibiotics was registered in 11/200 tests.
将新型脂肽抗生素LY146032与万古霉素、替考拉宁、头孢孟多和环丙沙星进行比较，以检测其对107株临床分离菌的抗菌活性，这些分离菌包括对甲氧西林敏感和耐药的葡萄球菌属、粪肠球菌和棒状杆菌属。所有葡萄球菌对所有药物均敏感，但部分耐甲氧西林菌株对头孢孟多耐药。只有LY146032和环丙沙星对粪肠球菌有杀菌作用。通过对10株选定菌株进行连续传代研究耐药性的产生。发现对所有受试药物，MIC在断点之上稳定地出现了至少8倍的增加，且程度各异。在200次试验中，有11次出现了对其他任何一种抗生素同时产生耐药性的情况。
