Ettinger Grace, MacDonald Kyle, Reid Gregor, Burton Jeremy P
a Canadian Center for Human Microbiome and Probiotic Research; Lawson Health Research Institute ; London , Ontario , Canada.
Gut Microbes. 2014;5(6):719-28. doi: 10.4161/19490976.2014.983775.
Cardiovascular disease (CVD) is a major cause of death worldwide. Of the many etiological factors, microorganisms constitute one. From the local impact of the gut microbiota on energy metabolism and obesity, to the distal association of periodontal disease with coronary heart disease, microbes have a significant impact on cardiovascular health. In terms of the ability to modulate or influence the microbes, probiotic applications have been considered. These are live microorganisms which when administered in adequate amounts confer a benefit on the host. While a number of reports have established the beneficial abilities of certain probiotic bacterial strains to reduce cholesterol and hypertension, recent research suggests that their use could be more widely applied. This review presents an up-to-date summary of the known associations of the microbiome with CVD, and potential applications of probiotic therapy.
心血管疾病（CVD）是全球主要的死亡原因之一。在众多病因中，微生物是其中一个因素。从肠道微生物群对能量代谢和肥胖的局部影响，到牙周疾病与冠心病的远端关联，微生物对心血管健康有着重大影响。就调节或影响微生物的能力而言，已考虑应用益生菌。益生菌是一类活的微生物，当给予足够数量时会对宿主产生益处。虽然许多报告已证实某些益生菌菌株具有降低胆固醇和高血压的有益能力，但最近的研究表明它们的用途可能会得到更广泛的应用。本综述提供了微生物群与心血管疾病已知关联以及益生菌疗法潜在应用的最新总结。
