亚单位流感疫苗研发的进展
Advancements in the development of subunit influenza vaccines.
作者信息
Zhang Naru, Zheng Bo-Jian, Lu Lu, Zhou Yusen, Jiang Shibo, Du Lanying
机构信息
Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.
Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong.
出版信息
Microbes Infect. 2015 Feb;17(2):123-34. doi: 10.1016/j.micinf.2014.12.006. Epub 2014 Dec 18.
Abstract
The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines.
摘要
流感流行和大流行的持续威胁凸显了研发针对不同流感病毒感染的安全有效疫苗的重要性。在本综述中，我们首先介绍甲型流感病毒的结构和生命周期，描述主要由甲型流感病毒引起的大流行。然后，我们比较不同类型的流感疫苗，并讨论亚单位流感疫苗开发的当前进展，特别是基于核蛋白（NP）、基质蛋白2（M2e）的胞外域和血凝素（HA）蛋白的疫苗。我们还阐述了提高亚单位流感疫苗效力的潜在策略。
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