内皮细胞衍生信号对组织形态发生的调控。
Regulation of tissue morphogenesis by endothelial cell-derived signals.
作者信息
Ramasamy Saravana K, Kusumbe Anjali P, Adams Ralf H
机构信息
Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine, D-48149 Münster, Germany.
Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine, D-48149 Münster, Germany.
出版信息
Trends Cell Biol. 2015 Mar;25(3):148-57. doi: 10.1016/j.tcb.2014.11.007. Epub 2014 Dec 17.
Endothelial cells (ECs) form an extensive network of blood vessels that has numerous essential functions in the vertebrate body. In addition to their well-established role as a versatile transport network, blood vessels can induce organ formation or direct growth and differentiation processes by providing signals in a paracrine (angiocrine) fashion. Tissue repair also requires the local restoration of vasculature. ECs are emerging as important signaling centers that coordinate regeneration and help to prevent deregulated, disease-promoting processes. Vascular cells are also part of stem cell niches and have key roles in hematopoiesis, bone formation, and neurogenesis. Here, we review these newly identified roles of ECs in the regulation of organ morphogenesis, maintenance, and regeneration.
内皮细胞（ECs）形成了一个广泛的血管网络，在脊椎动物体内具有许多重要功能。除了作为多功能运输网络所确立的作用外，血管还可以通过以旁分泌（血管分泌）方式提供信号来诱导器官形成或指导生长和分化过程。组织修复也需要局部血管系统的恢复。内皮细胞正在成为重要的信号中心，协调再生并有助于预防失调的、促进疾病的过程。血管细胞也是干细胞微环境的一部分，在造血、骨形成和神经发生中起关键作用。在这里，我们综述了内皮细胞在器官形态发生、维持和再生调节中的这些新发现的作用。
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