Gholipour Taha, Ghazizadeh Taher, Babapour Sahand, Mansouri Behzad, Ghafarpour Majid, Siroos Bahaadin, Harirchian Mohammad Hossein
Iranian Center of Neurological Research and Interdisciplinary Neuroscience Research Program, Tehran University of Medical Sciences, Tehran, Iran.
Section of Neurology, Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Iran J Allergy Asthma Immunol. 2015 Feb;14(1):91-7.
Melatonin has both pro-inflammatory and anti-inflammatory properties depending on the stage of inflammation. Despite its therapeutic effect in alleviation of some symptoms of multiple sclerosis; the precise role of melatonin in MS pathogenesis remains a topic of debate. The aim of this study was to measure the urine level of one of melatonin products which is an index of serum melatonin level, in MS patients in the acute phase of relapse and control patients. We also analyzed different clinical and cognitive indices in order to find any correlation with melatonin level. Twenty eight patients who were diagnosed as relapsing-remitting MS, according to the revised McDonald criteria, along with 10 age- and sex-matched control subjects were recruited in our study. Here we showed that urine 6-sulphatoxymelatonin levels (aMT6s; the major metabolite of melatonin) were significantly lower in MS patients compared to control group. Interestingly, urine aMT6s levels significantly correlated with MS Functional Composite score, but not Expanded Disability Severity Score. Based on above findings, there might be new hope in developing a quantitative and objective measure to assess the MS severity especially in neurodegenerative diseases. However, our results should be analyzed cautiously. We didn't evaluate simultaneous level of 25-OH Vitamin D. It has been recently reported that there is a negative correlation between melatonin and vitamin D levels. Further studies are needed to confirm this hypothesis.
褪黑素根据炎症阶段具有促炎和抗炎特性。尽管其在缓解多发性硬化症的某些症状方面具有治疗作用，但褪黑素在多发性硬化症发病机制中的精确作用仍是一个有争议的话题。本研究的目的是测量褪黑素一种产物的尿液水平（其为血清褪黑素水平的指标），该指标在复发急性期的多发性硬化症患者和对照患者中进行测量。我们还分析了不同的临床和认知指标，以发现与褪黑素水平的任何相关性。根据修订的麦克唐纳标准，28名被诊断为复发缓解型多发性硬化症的患者以及10名年龄和性别匹配的对照受试者被纳入我们的研究。在此我们表明，与对照组相比，多发性硬化症患者的尿液6 - 硫酸氧褪黑素水平（aMT6s；褪黑素的主要代谢产物）显著降低。有趣的是，尿液aMT6s水平与多发性硬化症功能综合评分显著相关，但与扩展残疾严重程度评分无关。基于上述发现，在开发一种定量和客观的方法来评估多发性硬化症严重程度方面可能有新的希望，尤其是在神经退行性疾病中。然而，我们的结果应谨慎分析。我们没有评估25 - 羟基维生素D的同时水平。最近有报道称褪黑素和维生素D水平之间存在负相关。需要进一步研究来证实这一假设。
