尿液中的尿素、尿酸和马尿酸作为多发性硬化症患者的潜在生物标志物。
Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients.
作者信息
Atya Hanaa B, Ali Sahar A, Hegazy Mohamed I, El Sharkawi Fathia Z
机构信息
1Biochemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
2Neurology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
出版信息
Indian J Clin Biochem. 2018 Apr;33(2):163-170. doi: 10.1007/s12291-017-0661-6. Epub 2017 May 22.
Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to investigate the level of some urinary metabolites (urea, uric acid and hippuric acid) in patients with MS and correlate their levels to the severity of the disease, MS subtypes and MS treatment. The urine samples were collected from 73 MS patients-48 with RRMS and 25 with SPMS- and age matched 75 healthy controls. The values of urinary urea, uric acid and hippuric acid in MS patients were significantly decreased, and these metabolites in SPMS pattern showed significantly decrease than RRMS pattern. Also showed significant inverse correlation with expanded disability status scale and number of relapses. Accordingly, they may act as a potential urinary biomarkers for MS, and correlate to disease progression.
尿液是已被证实的代谢物生物标志物来源，有潜力成为一种用于多种人类疾病的快速、无创、廉价且高效的诊断工具。尽管有这些优点，但尿液作为多发性硬化症（MS）生物标志物的来源却未得到充分研究。目的是调查MS患者尿液中某些代谢物（尿素、尿酸和马尿酸）的水平，并将其水平与疾病严重程度、MS亚型及MS治疗相关联。从73例MS患者（48例复发缓解型多发性硬化症患者和25例继发进展型多发性硬化症患者）以及年龄匹配的75名健康对照者中采集尿液样本。MS患者尿液中尿素、尿酸和马尿酸的值显著降低，且继发进展型多发性硬化症模式下的这些代谢物比复发缓解型多发性硬化症模式下显著降低。还显示与扩展残疾状态量表及复发次数呈显著负相关。因此，它们可能作为MS潜在的尿液生物标志物，并与疾病进展相关。
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