Keenan C M, Baker J, Bradley A, Goodman D G, Harada T, Herbert R, Kaufmann W, Kellner R, Mahler B, Meseck E, Nolte T, Rittinghausen S, Vahle J, Yoshizawa K
C. M. Keenan ToxPath Consulting, Doylestown, Pennsylvania, USA
Charles River Pathology Associates, Frederick, Maryland, USA.
Toxicol Pathol. 2015 Jul;43(5):730-2. doi: 10.1177/0192623314560031. Epub 2014 Dec 21.
The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice proposal (INHAND) has been operational since 2005. A Global Editorial Steering Committee manages the overall objectives of the project, and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups, drawing upon experts from North America, Europe, and Japan. Great progress has been made with 9 systems published to date--respiratory, hepatobiliary, urinary, central/peripheral nervous systems, male reproductive and mammary, zymbals, clitoral, and preputial glands in Toxicologic Pathology and the integument and soft tissue and female reproductive in the Journal of Toxicologic Pathology as supplements and on a Web site--www.goReni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photomicrographs of morphologic changes, information regarding pathogenesis, and key references. The purpose of this brief communication is to provide an update on the progress of INHAND.
大鼠和小鼠病变命名与诊断标准国际协调提案（INHAND）自2005年起开始运作。一个全球编辑指导委员会负责管理该项目的总体目标，每个器官系统统一术语的制定由器官工作组负责，这些工作组汇聚了来自北美、欧洲和日本的专家。迄今为止，已取得了重大进展，已有9个系统发布——在《毒理病理学》上发表的呼吸系统、肝胆系统、泌尿系统、中枢/外周神经系统、雄性生殖和乳腺、鼓腺、阴蒂腺和包皮腺，以及在《毒理病理学杂志》增刊和网站（www.goReni.org）上发表的皮肤和软组织及雌性生殖系统。INHAND命名指南提供了在啮齿动物毒性和致癌性研究中观察到的病变的诊断标准和记录指南。这些指南提供了形态学变化的代表性显微照片、发病机制信息和关键参考文献。本简短通讯的目的是提供INHAND进展的最新情况。
