支持与研究实施的伦理：早产儿氧疗试验对比较效果研究的启示
SUPPORT and the Ethics of Study Implementation: Lessons for Comparative Effectiveness Research from the Trial of Oxygen Therapy for Premature Babies.
作者信息
Lantos John D, Feudtner Chris
出版信息
Hastings Cent Rep. 2015 Jan-Feb;45(1):30-40. doi: 10.1002/hast.407. Epub 2014 Dec 19.
Abstract
The design of SUPPORT has been widely misunderstood. This confusion has driven much of the debate about the trial - and threatens the whole enterpise of comparative effectiveness research.
摘要
SUPPORT的设计被广泛误解了。这种混淆引发了关于该试验的诸多争论——并威胁到了整个比较效果研究事业。
相似文献
1
SUPPORT and the Ethics of Study Implementation: Lessons for Comparative Effectiveness Research from the Trial of Oxygen Therapy for Premature Babies.支持与研究实施的伦理：早产儿氧疗试验对比较效果研究的启示
Hastings Cent Rep. 2015 Jan-Feb;45(1):30-40. doi: 10.1002/hast.407. Epub 2014 Dec 19.
2
Were There "Additional Foreseeable Risks" in the SUPPORT Study? Lessons Not Learned from the ARDSnet Clinical Trials.SUPPORT研究中存在“其他可预见风险”吗？ARDSnet临床试验未吸取的教训。
Hastings Cent Rep. 2015 Jan-Feb;45(1):21-9. doi: 10.1002/hast.403. Epub 2014 Dec 19.
3
SUPPORT and Comparative Effectiveness Trials: What's at Stake?支持性试验和比较效果试验：风险何在？
Hastings Cent Rep. 2015 Jan-Feb;45(1):44-5. doi: 10.1002/hast.417.
4
SUPPORT: Risks, Harms, and Equipoise.支持：风险、危害与均衡
Hastings Cent Rep. 2015 Jan-Feb;45(1):40-2. doi: 10.1002/hast.415.
5
What counts as equipoise?什么才算得上 equipoise？
Hastings Cent Rep. 2015 May-Jun;45(3):3-4. doi: 10.1002/hast.437.
6
The author replies.作者回复。
Hastings Cent Rep. 2015 May-Jun;45(3):4. doi: 10.1002/hast.438.
7
The potential harms and benefits from research on medical practices.医学实践研究的潜在危害与益处。
Hastings Cent Rep. 2015 May-Jun;45(3):5-6. doi: 10.1002/hast.440.
8
The Controversy over SUPPORT Continues and the Hyperbole Increases.关于“支持性护理计划”（SUPPORT）的争议仍在继续，夸张之词也越来越多。
Hastings Cent Rep. 2015 Jan-Feb;45(1):42-4. doi: 10.1002/hast.416.
9
Muddled measures of risks and misremembered reasons.混乱的风险衡量与记错的原因。
Hastings Cent Rep. 2015 May-Jun;45(3):4-5. doi: 10.1002/hast.439.
10
Ongoing Controversy over SUPPORT.关于SUPPORT的持续争议。
Hastings Cent Rep. 2015 Jan-Feb;45(1):2. doi: 10.1002/hast.405.
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本文引用的文献
1
Comparative effectiveness trials: generic misassumptions underlying the SUPPORT controversy.比较效果试验：支持疗法争议背后的一般错误假设。
Pediatrics. 2014 Oct;134(4):651-4. doi: 10.1542/peds.2013-4176. Epub 2014 Sep 8.
2
Personalized medicine in the NICU.新生儿重症监护病房中的个性化医疗。
Am J Bioeth. 2013;13(12):33-5. doi: 10.1080/15265161.2013.849310.
3
The weird divergence of ethics and regulation with regard to informed consent.在知情同意方面，伦理与监管出现了奇怪的分歧。
Am J Bioeth. 2013;13(12):31-3. doi: 10.1080/15265161.2013.849308.
4
SUPPORT asked the wrong question.SUPPORT问了错误的问题。
Am J Bioeth. 2013;13(12):25-6. doi: 10.1080/15265161.2013.851300.
5
Informed consent and standard of care: what must be disclosed.知情同意与医疗标准：哪些必须披露。
Am J Bioeth. 2013;13(12):9-13. doi: 10.1080/15265161.2013.849303.
6
Ethics and informed consent for comparative effectiveness research with prospective electronic clinical data.具有前瞻性电子临床数据的比较有效性研究的伦理学和知情同意。
Med Care. 2013 Aug;51(8 Suppl 3):S53-7. doi: 10.1097/MLR.0b013e31829b1e4b.
7
Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial.以更高与更低目标动脉血氧饱和度对极早产儿死亡或残疾的影响：一项随机临床试验。
JAMA. 2013 May 22;309(20):2111-20. doi: 10.1001/jama.2013.5555.
8
Oxygen saturation and outcomes in preterm infants.早产儿的氧饱和度与结局。
N Engl J Med. 2013 May 30;368(22):2094-104. doi: 10.1056/NEJMoa1302298. Epub 2013 May 5.
9
Default options and neonatal resuscitation decisions.默认选项和新生儿复苏决策。
J Med Ethics. 2012 Dec;38(12):713-8. doi: 10.1136/medethics-2011-100182.
10
Antenatal counselling for parents facing an extremely preterm birth: limitations of the medical evidence.针对极早产儿出生的父母进行产前咨询：医学证据的局限性。
Acta Paediatr. 2012 Aug;101(8):800-4. doi: 10.1111/j.1651-2227.2012.02695.x. Epub 2012 May 4.
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