Amatachaya Anuwat, Auvichayapat Narong, Patjanasoontorn Niramol, Suphakunpinyo Chanyut, Ngernyam Niran, Aree-Uea Benchaporn, Keeratitanont Keattichai, Auvichayapat Paradee
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Behav Neurol. 2014;2014:173073. doi: 10.1155/2014/173073. Epub 2014 Oct 30.
The aim of this study was to evaluate the Childhood Autism Rating Scale (CARS), Autism Treatment Evaluation Checklist (ATEC), and Children's Global Assessment Scale (CGAS) after anodal transcranial direct current stimulation (tDCS) in individuals with autism. Twenty patients with autism received 5 consecutive days of both sham and active tDCS stimulation (1 mA) in a randomized double-blind crossover trial over the left dorsolateral prefrontal cortex (F3) for 20 minutes in different orders. Measures of CARS, ATEC, and CGAS were administered before treatment and at 7 days posttreatment. The result showed statistical decrease in CARS score (P < 0.001). ATEC total was decreased from 67.25 to 58 (P < 0.001). CGAS was increased at 7 days posttreatment (P = 0.042). Our study suggests that anodal tDCS over the F3 may be a useful clinical tool in autism.
本研究的目的是评估经颅直流电刺激（tDCS）阳极刺激对自闭症患者的儿童自闭症评定量表（CARS）、自闭症治疗评估清单（ATEC）和儿童总体评定量表（CGAS）的影响。在一项随机双盲交叉试验中，20名自闭症患者以不同顺序在左侧背外侧前额叶皮质（F3）接受连续5天的假刺激和阳极tDCS刺激（1毫安），每次刺激20分钟。在治疗前和治疗后7天进行CARS、ATEC和CGAS测量。结果显示CARS评分有统计学意义的下降（P<0.001）。ATEC总分从67.25降至58（P<0.001）。治疗后7天CGAS升高（P = 0.042）。我们的研究表明，F3区阳极tDCS可能是自闭症治疗中一种有用的临床工具。
