通过机械和生化手段调节神经组织对植入微电极反应的材料方法。
Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means.
作者信息
Sommakia Salah, Lee Heui C, Gaire Janak, Otto Kevin J
机构信息
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-1791.
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1791.
出版信息
Curr Opin Solid State Mater Sci. 2014 Dec 1;18(6):319-328. doi: 10.1016/j.cossms.2014.07.005.
Abstract
Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use. Their potential for treating a wide range of traumatic and degenerative neural disease is hampered by their unreliability in chronic settings. A major factor in this decline in chronic performance is a reactive response of brain tissue, which aims to isolate the implanted device from the rest of the healthy tissue. In this review we present a discussion of materials approaches aimed at modulating the reactive tissue response through mechanical and biochemical means. Benefits and challenges associated with these approaches are analyzed, and the importance of multimodal solutions tested in emerging animal models are presented.
摘要
可植入式皮层内微电极在广泛临床应用上面临着艰巨的挑战。它们在治疗多种创伤性和退行性神经疾病方面的潜力因在慢性环境中的不可靠性而受到阻碍。慢性性能下降的一个主要因素是脑组织的反应性反应，其目的是将植入装置与其余健康组织隔离开来。在这篇综述中，我们讨论了旨在通过机械和生化手段调节反应性组织反应的材料方法。分析了与这些方法相关的益处和挑战，并介绍了在新兴动物模型中测试的多模式解决方案的重要性。
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J Mater Chem B. 2014 Apr 28;2(16):2248-2258. doi: 10.1039/C4TB00125G.
2
Biological, mechanical, and technological considerations affecting the longevity of intracortical electrode recordings.影响皮层内电极记录寿命的生物学、机械和技术因素。
Crit Rev Biomed Eng. 2013;41(6):435-56.
3
The Effect of Residual Endotoxin Contamination on the Neuroinflammatory Response to Sterilized Intracortical Microelectrodes.残留内毒素污染对无菌皮质内微电极神经炎症反应的影响。
J Mater Chem B. 2014 May 7;2(17):2517-2529. doi: 10.1039/C3TB21453B.
4
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Acta Biomater. 2014 May;10(5):2209-22. doi: 10.1016/j.actbio.2014.01.018. Epub 2014 Jan 24.
5
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