Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Department of Agriculture Biology, Faculty of Agriculture, University of Ruhuna, 81100 Wellmadama, Matara, Sri Lanka.
Evid Based Complement Alternat Med. 2014;2014:143782. doi: 10.1155/2014/143782. Epub 2014 Oct 30.
Honey, a supersaturated natural product of honey bees, contains complex compounds with antioxidant properties and therefore has a wide a range of applications in both traditional and modern medicine. In the present study, the protective effects of Sundarban honey from Bangladesh against acetaminophen- (APAP-) induced hepatotoxicity and nephrotoxicity in experimental rats were investigated. Adult male Wistar rats were pretreated with honey (5 g/kg) for 4 weeks, followed by the induction of hepatotoxicity and nephrotoxicity via the oral administration of a single dose of APAP (2 g/kg). Organ damage was confirmed by measuring the elevation of serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), total protein (TP), total bilirubin (TB), urea, creatinine, and malondialdehyde (MDA). Histopathological alterations observed in the livers and the kidneys further confirmed oxidative damage to these tissues. Animals pretreated with Sundarban honey showed significantly markedly reduced levels of all of the investigated parameters. In addition, Sundarban honey ameliorated the altered hepatic and renal morphology in APAP-treated rats. Overall, our findings indicate that Sundarban honey protects against APAP-induced acute hepatic and renal damage, which could be attributed to the honey's antioxidant properties.
亲爱的，蜂蜜是蜜蜂产生的一种过饱和天然产物，含有具有抗氧化特性的复杂化合物，因此在传统和现代医学中具有广泛的应用。在本研究中，研究了来自孟加拉国的孙德尔本斯蜂蜜对实验大鼠醋氨酚（APAP）诱导的肝毒性和肾毒性的保护作用。成年雄性 Wistar 大鼠用蜂蜜（5 g/kg）预处理 4 周，然后通过口服单次给予 2 g/kg 的 APAP 诱导肝毒性和肾毒性。通过测量血清碱性磷酸酶（ALP）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总蛋白（TP）、总胆红素（TB）、尿素、肌酐和丙二醛（MDA）的升高来确认器官损伤。在肝脏和肾脏中观察到的组织病理学改变进一步证实了这些组织的氧化损伤。用孙德尔本斯蜂蜜预处理的动物显示出所有研究参数的水平明显显著降低。此外，孙德尔本斯蜂蜜改善了 APAP 处理大鼠的肝和肾形态改变。总的来说，我们的研究结果表明，孙德尔本斯蜂蜜可预防 APAP 引起的急性肝和肾损伤，这可能归因于蜂蜜的抗氧化特性。
