通过补充L-精氨酸、L-瓜氨酸、刺梨提取物和碧萝芷®的组合，男性的精子质量得到改善。

Sperm quality in men is improved by supplementation with a combination of L-arginine, L-citrullin, roburins and Pycnogenol®.

作者信息

Stanislavov R, Rohdewald P

机构信息

Institute of Pharmacy, University of Münster, Münster, Germany -

出版信息

Minerva Urol Nefrol. 2014 Dec;66(4):217-23.

PMID:25531191

Abstract

AIM

The aim of this study was to investigate the influence of Prelox®R, a combination of French maritime pine bark extract (Pycnogenol®), L-arginine, L-citrulline and roburins, on male fertility.

METHODS

Sperm quality of 50 subfertile men was tested in monthly intervals in a double-blind, randomized, placebo controlled, crossover study. Patients received 2 tablets Prelox®R or placebo twice daily during test periods. Following a run-in period of 1 month, patients received either Prelox®R or a placebo for 1 month. After a wash-out period of 1 month, patients received Prelox®R or a placebo in a crossover manner for 1 month. Sperm volume, concentration of spermatozoa, total count, motility, vitality and morphology were measured by standard methods of calculation of the Fertility Index (FI) in monthly intervals. Activity of e-NOS in sperm was evaluated in parallel by measuring the quantity of L-citulline produced from L-arginine.

RESULTS

Supplementation with Prelox®R enhanced sperm volume and concentration, motility, vitality and morphology significantly versus placebo. The Fertility Index rose to normal values during treatment with Prelox®R. e-NOS activity in sperm was elevated by Prelox®R. No adverse effects were reported.

CONCLUSION

Prelox®R offers a safe method to improve quality of human spermatozoa in subfertile men.

摘要

目的

本研究旨在探讨Prelox®R（一种法国滨海松树皮提取物（碧萝芷®）、L-精氨酸、L-瓜氨酸和红杉醇的组合）对男性生育能力的影响。

方法

在一项双盲、随机、安慰剂对照、交叉研究中，每月对50名不育男性的精子质量进行检测。在测试期间，患者每天服用2片Prelox®R或安慰剂，分两次服用。经过1个月的导入期后，患者服用Prelox®R或安慰剂1个月。在1个月的洗脱期后，患者交叉服用Prelox®R或安慰剂1个月。每月通过生育指数（FI）的标准计算方法测量精子体积、精子浓度、总数、活力、存活率和形态。通过测量由L-精氨酸产生的L-瓜氨酸的量，平行评估精子中e-NOS的活性。