Bai Li-Yuan, Lin Wei-Yu, Chiu Chang-Fang, Weng Jing-Ru
Nat Prod Commun. 2014 Nov;9(11):1557-8.
In this study, we report the isolation from the stem of Syzygium kusukusense of five triterpenes, 2α-hydroxybetulinic acid (1), betulinic acid (2), platanic acid (3), ursolic acid (4), and hyptatic acid A (5). All were identified for the first time from this indigenous plant of Taiwan. Assessment of the cytotoxic activities of these compounds against a panel of human tumor cell lines, including MCF-7 breast, PC-3 prostate, and SCC2095 oral squamous cell cancers, revealed the high potency of compounds 1 (IC50, 5.7 - 7.6 μM) and, especially, 4 (IC50, 1.7 - 3.7 μM) in suppressing cell viability, which warrants further mechanistic investigations.
在本研究中，我们报告了从库氏蒲桃茎中分离出5种三萜类化合物，即2α-羟基桦木酸（1）、桦木酸（2）、悬铃木酸（3）、熊果酸（4）和鸭脚茶酸A（5）。所有这些化合物均首次从台湾本土植物中鉴定出来。对这些化合物针对一组人类肿瘤细胞系（包括MCF-7乳腺癌细胞、PC-3前列腺癌细胞和SCC2095口腔鳞状癌细胞）的细胞毒性活性进行评估，结果显示化合物1（IC50，5.7 - 7.6 μM），尤其是化合物4（IC50，1.7 - 3.7 μM）在抑制细胞活力方面具有高效性，这值得进一步进行机制研究。
