Hynowska A, Blanquer A, Pellicer E, Fornell J, Suriñach S, Baró M D, Gebert A, Calin M, Eckert J, Nogués C, Ibáñez E, Barrios L, Sort J
Departament de Física, Universitat Autònoma de Barcelona, Bellaterra, E-08193, Spain.
Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, E-08193, Spain.
J Biomed Mater Res B Appl Biomater. 2015 Nov;103(8):1569-79. doi: 10.1002/jbm.b.33346. Epub 2014 Dec 23.
The microstructure, mechanical behaviour, and biocompatibility (cell culture, morphology, and cell adhesion) of nanostructured Ti45 Zr15 Pd35- x Si5 Nbx with x = 0, 5 (at. %) alloys, synthesized by arc melting and subsequent Cu mould suction casting, in the form of rods with 3 mm in diameter, are investigated. Both Ti-Zr-Pd-Si-(Nb) materials show a multi-phase (composite-like) microstructure. The main phase is cubic β-Ti phase (Im3m) but hexagonal α-Ti (P63/mmc), cubic TiPd (Pm3m), cubic PdZr (Fm3m), and hexagonal (Ti, Zr)5 Si3 (P63/mmc) phases are also present. Nanoindentation experiments show that the Ti45 Zr15 Pd30 Si5 Nb5 sample exhibits lower Young's modulus than Ti45 Zr15 Pd35 Si5 . Conversely, Ti45 Zr15 Pd35 Si5 is mechanically harder. Actually, both alloys exhibit larger values of hardness when compared with commercial Ti-40Nb, (HTi-Zr-Pd-Si ≈ 14 GPa, HTi-Zr-Pd-Si-Nb ≈ 10 GPa and HTi-40Nb ≈ 2.7 GPa). Concerning the biological behaviour, preliminary results of cell viability performed on several Ti-Zr-Pd-Si-(Nb) discs indicate that the number of live cells is superior to 94% in both cases. The studied Ti-Zr-Pd-Si-(Nb) bulk metallic system is thus interesting for biomedical applications because of the outstanding mechanical properties (relatively low Young's modulus combined with large hardness), together with the excellent biocompatibility.
研究了通过电弧熔炼和随后的铜模吸铸法合成的直径为3mm的棒状纳米结构Ti45Zr15Pd35 - xSi5Nbx（x = 0、5（原子％））合金的微观结构、力学行为和生物相容性（细胞培养、形态和细胞粘附）。Ti-Zr-Pd-Si-(Nb)材料均呈现多相（类复合材料）微观结构。主要相为立方β-Ti相（Im3m），但也存在六方α-Ti（P63/mmc）、立方TiPd（Pm3m）、立方PdZr（Fm3m）和六方（Ti,Zr）5Si3（P63/mmc）相。纳米压痕实验表明，Ti45Zr15Pd30Si5Nb5样品的杨氏模量低于Ti45Zr15Pd35Si5。相反，Ti45Zr15Pd35Si5在机械性能上更硬。实际上，与商用Ti-40Nb相比，这两种合金都表现出更大的硬度值（HTi-Zr-Pd-Si≈14 GPa，HTi-Zr-Pd-Si-Nb≈10 GPa，HTi-40Nb≈2.7 GPa）。关于生物学行为，在几个Ti-Zr-Pd-Si-(Nb)圆盘上进行的细胞活力初步结果表明，两种情况下活细胞数量均超过94％。因此，所研究的Ti-Zr-Pd-Si-(Nb)块状金属体系因其出色的机械性能（相对较低的杨氏模量与较大的硬度相结合）以及优异的生物相容性而在生物医学应用中具有吸引力。
