Miettinen T A, Tarpila S
Second Department of Medicine, University of Helsinki, Finland.
Clin Chim Acta. 1989 Aug 31;183(3):253-62. doi: 10.1016/0009-8981(89)90359-8.
Short-term viscous dietary fibres, plantago ovata and guar gum preparations, decreased serum cholesterol, mainly LDL cholesterol, as compared to low fibre or nonviscous high fibre periods, through enhancing cholesterol elimination as fecal bile acids. These changes were associated with significant increases in serum levels of cholesterol precursors, both in methylsterols and demethylated precursor sterols, while that of cholestanol (saturated cholesterol derivative) was decreased. In addition, cholesterol precursor contents were positively related, cholestanol negatively, to fecal cholesterol elimination both on and off viscous fibres. These findings indicate increased cholesterol synthesis, also seen by sterol balance data. As compared to low fibre diet, nonviscous high fibre diet conserved bile acids and decreased cholesterol absorption. Thus, it had no effect on cholesterol synthesis as indicated by fecal total steroids or serum levels of cholesterol precursors.
与低纤维或非粘性高纤维时期相比，短期粘性膳食纤维、车前草籽和瓜尔胶制剂通过增加粪便胆汁酸形式的胆固醇排泄，降低了血清胆固醇，主要是低密度脂蛋白胆固醇。这些变化与血清中胆固醇前体（包括甲基甾醇和去甲基化前体甾醇）水平的显著升高相关，而胆甾烷醇（饱和胆固醇衍生物）水平降低。此外，无论是否摄入粘性纤维，胆固醇前体含量与粪便胆固醇排泄呈正相关，胆甾烷醇与粪便胆固醇排泄呈负相关。这些发现表明胆固醇合成增加，这也通过甾醇平衡数据得到证实。与低纤维饮食相比，非粘性高纤维饮食可保留胆汁酸并减少胆固醇吸收。因此，如粪便总类固醇或胆固醇前体的血清水平所示，它对胆固醇合成没有影响。
