*Department of Dermatology, Faculty of Medicine, University of Kufa, Kufa, Iraq; †Department of Dermatology, Al-Sadir Medical City, Najaf Health Directorate, Najaf, Iraq.
Dermatol Surg. 2015 Jan;41(1):136-41. doi: 10.1097/DSS.0000000000000238.
Frictional dermal melanosis over bony prominences (Lifa disease) is a common pigmentary skin disorder in Iraqi patients. Q-switched lasers are the gold standard treatment of correcting pigmentation; among them are the 532-nm and 1,064-nm lasers.
To evaluate the efficacy of these lasers in the treatment of hyperpigmentation due to Lifa disease.
A prospective, comparative, controlled, split-lesion clinical trial study was designed. Nineteen female patients with clinical diagnosis of Lifa disease were enrolled. Each patient was treated for 3 sessions at 2-week intervals. A 532-nm Q-switched Nd:YAG laser was used on the left side and 1,064-nm on the right side of each lesion. Both objective and subjective parameters were assessed 1 and 3 months after the last treatment session. Darkness score, photographic assessment and patient satisfaction, and improvement of itch were recorded, respectively.
Seventeen patients completed the study. The color score changes of both sides demonstrated that although both lasers were effective in reducing the pigmentation, the 1,064-nm wavelength had a more significant response. Similar results were obtained for the photographic evaluations and patient satisfaction scores. These changes were sustained throughout the 3 month follow-up.
Both lasers were effective in the treatment of pigmentation abnormalities caused by Lifa disease. However, the efficacy was greater with the 1,064-nm wavelength.
摩擦性皮肤黑色素沉着症（Lifa 病）是伊拉克患者常见的色素性皮肤病。调 Q 激光是纠正色素沉着的金标准治疗方法；其中包括 532nm 和 1064nm 激光。
评估这些激光治疗 Lifa 病引起的色素沉着过度的疗效。
设计了一项前瞻性、对照、控制、分侧临床试验研究。招募了 19 名患有 Lifa 病临床诊断的女性患者。每位患者每 2 周接受 3 次治疗。在每个病变的左侧使用 532nm 调 Q 钕：YAG 激光，右侧使用 1064nm 激光。在最后一次治疗后 1 个月和 3 个月分别评估客观和主观参数。记录黑暗评分、摄影评估和患者满意度，以及瘙痒改善情况。
17 名患者完成了研究。两侧的颜色评分变化表明，虽然两种激光都能有效减少色素沉着，但 1064nm 波长的反应更为显著。摄影评估和患者满意度评分也得到了类似的结果。这些变化在整个 3 个月的随访中持续存在。
两种激光均能有效治疗 Lifa 病引起的色素异常。然而，1064nm 波长的疗效更大。
