• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

真核生物透明质酸合酶的鉴定与调控

Identification and regulation of the eukaryotic hyaluronate synthase.

作者信息

Prehm P

机构信息

Institut für Physiologische Chemie, Münster, Federal Republic of Germany.

出版信息

Ciba Found Symp. 1989;143:21-30; discussion 30-40, 281-5. doi: 10.1002/9780470513774.ch3.

DOI:10.1002/9780470513774.ch3
PMID:2553354
Abstract

Hyaluronate synthesis is required for fibroblast detachment in mitosis and migration. It is regulated by the activity of the synthase which is localized at the inner side of plasma membranes. The synthase was identified as a 50 kDa protein by immunological cross-reaction with the streptococcal enzyme and by affinity labelling. Transformation of fibroblasts by Rous sarcoma virus activated the synthase by enhanced transcription and phosphorylation. The synthase was a natural target of pp60v-src kinase.

摘要

透明质酸盐的合成是成纤维细胞在有丝分裂和迁移过程中脱离所必需的。它受位于质膜内侧的合酶活性调节。通过与链球菌酶的免疫交叉反应和亲和标记，该合酶被鉴定为一种50 kDa的蛋白质。劳氏肉瘤病毒对成纤维细胞的转化通过增强转录和磷酸化激活了该合酶。该合酶是pp60v-src激酶的天然靶点。

相似文献

1
Identification and regulation of the eukaryotic hyaluronate synthase.真核生物透明质酸合酶的鉴定与调控
Ciba Found Symp. 1989;143:21-30; discussion 30-40, 281-5. doi: 10.1002/9780470513774.ch3.
2
Isolation of streptococcal hyaluronate synthase.链球菌透明质酸合酶的分离
Biochem J. 1986 May 1;235(3):887-9. doi: 10.1042/bj2350887.
3
Analysis of cell-growth-phase-related variations in hyaluronate synthase activity of isolated plasma-membrane fractions of cultured human skin fibroblasts.培养的人皮肤成纤维细胞分离的质膜组分中透明质酸合酶活性与细胞生长阶段相关变化的分析。
Biochem J. 1986 Jul 15;237(2):333-42. doi: 10.1042/bj2370333.
4
Increased hyaluronate synthesis is required for fibroblast detachment and mitosis.成纤维细胞脱离和有丝分裂需要增加透明质酸的合成。
Biochem J. 1986 Oct 15;239(2):445-50. doi: 10.1042/bj2390445.
5
The hyaluronate synthase from a eukaryotic cell line.来自真核细胞系的透明质酸合酶。
Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):791-5. doi: 10.1042/bj2900791.
6
Characterization of a high-Mr plasma-membrane-bound protein and assessment of its role as a constituent of hyaluronate synthase complex.一种高分子量质膜结合蛋白的特性鉴定及其作为透明质酸合酶复合体组成成分的作用评估。
Biochem J. 1986 Jul 15;237(2):343-57. doi: 10.1042/bj2370343.
7
Shedding of hyaluronate synthase from streptococci.透明质酸合酶从链球菌中的脱落。
Biochem J. 1990 Apr 1;267(1):191-6. doi: 10.1042/bj2670191.
8
Synthesis of hyaluronate in differentiated teratocarcinoma cells. Characterization of the synthase.分化型畸胎瘤细胞中透明质酸的合成。合成酶的特性
Biochem J. 1983 Apr 1;211(1):181-9. doi: 10.1042/bj2110181.
9
The effect of the tumor promoter, phorbol myristate acetate (PMA), on hyaluronic acid (HA) synthesis by chicken embryo fibroblasts.肿瘤促进剂佛波酯（PMA）对鸡胚成纤维细胞透明质酸（HA）合成的影响。
Exp Cell Res. 1983 Oct 15;148(2):377-86. doi: 10.1016/0014-4827(83)90160-x.
10
Analysis of the streptococcal hyaluronic acid synthase complex using the photoaffinity probe 5-azido-UDP-glucuronic acid.使用光亲和探针5-叠氮基-UDP-葡萄糖醛酸对链球菌透明质酸合酶复合物进行分析。
J Biol Chem. 1992 Dec 5;267(34):24302-6.

引用本文的文献

1
Hyaluronan synthases; mechanisms, myths, & mysteries of three types of unique bifunctional glycosyltransferases.透明质酸合酶；三种独特双功能糖基转移酶的机制、神话和奥秘。
Glycobiology. 2023 Dec 30;33(12):1117-1127. doi: 10.1093/glycob/cwad075.
2
Modulation of hyaluronan signaling as a therapeutic target in human disease.透明质酸信号转导的调控作为人类疾病的治疗靶点。
Pharmacol Ther. 2022 Apr;232:107993. doi: 10.1016/j.pharmthera.2021.107993. Epub 2021 Sep 26.
3
Hyaluronan and halogen-induced airway hyperresponsiveness and lung injury.
透明质酸和卤素诱导的气道高反应性和肺损伤。
Ann N Y Acad Sci. 2020 Nov;1479(1):29-43. doi: 10.1111/nyas.14415. Epub 2020 Jun 23.
4
Endothelial Glycocalyx as a Shield Against Diabetic Vascular Complications: Involvement of Hyaluronan and Hyaluronidases.内皮糖萼作为抵御糖尿病血管并发症的盾牌：透明质酸和透明质酸酶的参与。
Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1427-1439. doi: 10.1161/ATVBAHA.118.310839. Epub 2018 Jun 7.
5
Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology.尺寸至关重要：透明质酸在细胞生物学中作用的分子量特异性
Int J Cell Biol. 2015;2015:563818. doi: 10.1155/2015/563818. Epub 2015 Sep 10.
6
Hyaluronan: a simple polysaccharide with diverse biological functions.透明质酸：一种具有多种生物学功能的简单多糖。
Acta Biomater. 2014 Apr;10(4):1558-70. doi: 10.1016/j.actbio.2013.12.019. Epub 2013 Dec 18.
7
Protease Activity and the Role of the Endothelial Glycocalyx in Inflammation.蛋白酶活性与内皮糖萼在炎症中的作用
Drug Discov Today Dis Models. 2011 Spring;8(1):57-62. doi: 10.1016/j.ddmod.2011.05.004.
8
Neural stem cell niches: roles for the hyaluronan-based extracellular matrix.神经干细胞龛：基于透明质酸的细胞外基质的作用。
Front Biosci (Schol Ed). 2011 Jun 1;3(3):1165-79. doi: 10.2741/218.
9
Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes.内皮糖萼的组成及其与厚度和小分子溶质扩散的关系。
Microvasc Res. 2010 Dec;80(3):394-401. doi: 10.1016/j.mvr.2010.06.005. Epub 2010 Jun 21.
10
Regulation of proteoglycan and hyaluronan synthesis by elevated level of intracellular cyclic adenosine monophosphate in peritubular cells from immature rat testis.未成熟大鼠睾丸肾小管周细胞内细胞内环磷酸腺苷水平升高对蛋白聚糖和透明质酸合成的调节
Mol Cell Biochem. 1998 Oct;187(1-2):99-112. doi: 10.1023/a:1006835810773.