Bull A R, Kimmance K J, Parry J V, Perry K R
Department of Community Medicine, Odstock Hospital, Salisbury, Wiltshire.
Epidemiol Infect. 1989 Oct;103(2):371-6. doi: 10.1017/s0950268800030715.
In March 1988 a general practitioner notified two cases of hepatitis A in a private boarding school. Epidemiological investigation, including testing for salivary antibodies revealed a further five cases and established immunity to, and recent infection with, hepatitis A virus (HAV). The pattern of the outbreak was described. A number of practices which would encourage cross-infection were corrected. Normal human immunoglobulin was given to contacts. Repeat salivary testing 10 weeks later revealed that two more boys had become reactive for anti-HAV, though at a low titre. These may have been serological responses to HAV infection modified by the passive immunization.
1988年3月，一名全科医生通报了一所私立寄宿学校发生的两例甲型肝炎病例。流行病学调查，包括唾液抗体检测，又发现了另外五例病例，并确定了对甲型肝炎病毒（HAV）的免疫力以及近期感染情况。描述了此次疫情的模式。纠正了一些可能会助长交叉感染的做法。对密切接触者给予了正常人免疫球蛋白。10周后重复进行唾液检测发现，又有两名男孩的抗-HAV呈阳性反应，不过滴度较低。这些可能是被动免疫对HAV感染产生的血清学反应。
