泰晤士河东北地区献血者的甲型肝炎抗体：对预防政策的影响。
Hepatitis A antibody in blood donors in North East Thames region: implications to prevention policies.
作者信息
Scott N J, Harrison J F, Zuckerman A J
机构信息
N.E. Thames Regional Blood Transfusion Centre, Brentwood, Essex.
出版信息
Epidemiol Infect. 1989 Oct;103(2):377-82. doi: 10.1017/s0950268800030727.
A total of 1786 blood donors were screened for the presence of anti-hepatitis A antibody (anti HAV). 64.5% of the donors were found to be positive. The prevalence of the antibody was found to be age-related, 55% at 18 years and 75% at 65 years. No relationship was noted between the presence of antibody, foreign travel or a specific destination. Assay of antibody levels in selected seropositive individuals gave a mean level of 5.0 IU/ml. The prevalence of infection in this selected population is important in the context of passive immunization with normal human immunoglobulin and for defining a policy of immunization with hepatitis A vaccines, which are currently undergoing clinical trials.
共对1786名献血者进行了抗甲型肝炎抗体（抗-HAV）筛查。发现64.5%的献血者呈阳性。该抗体的流行率与年龄相关，18岁时为55%，65岁时为75%。未发现抗体的存在与出国旅行或特定目的地之间存在关联。对选定的血清阳性个体的抗体水平检测得出平均水平为5.0 IU/ml。在使用正常人免疫球蛋白进行被动免疫以及确定目前正在进行临床试验的甲型肝炎疫苗免疫策略的背景下，这一选定人群中的感染流行率具有重要意义。
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