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本文引用的文献

1
Clostridium difficile erm(B)-containing elements and the burden on the in vitro fitness.含 erm(B) 的艰难梭菌元素和对体外适应性的负担。
J Med Microbiol. 2013 Sep;62(Pt 9):1461-1467. doi: 10.1099/jmm.0.057117-0. Epub 2013 Jun 5.
2
Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production.精确操纵艰难梭菌染色体表明 tcdC 基因型与毒素产生之间缺乏关联。
Appl Environ Microbiol. 2012 Jul;78(13):4683-90. doi: 10.1128/AEM.00249-12. Epub 2012 Apr 20.
3
Impact of fluoroquinolone resistance mutations on gonococcal fitness and in vivo selection for compensatory mutations.氟喹诺酮耐药突变对淋球菌适应性和体内补偿性突变选择的影响。
J Infect Dis. 2012 Jun 15;205(12):1821-9. doi: 10.1093/infdis/jis277. Epub 2012 Apr 5.
4
Fitness cost of fluoroquinolone resistance in Campylobacter coli and Campylobacter jejuni.氟喹诺酮耐药性在结肠弯曲菌和空肠弯曲菌中的致弱效应
Microb Drug Resist. 2011 Jun;17(2):171-9. doi: 10.1089/mdr.2010.0139. Epub 2011 Mar 9.
5
Antimicrobial susceptibility and heteroresistance in Chinese Clostridium difficile strains.中国艰难梭菌菌株的抗菌敏感性和异质性耐药性。
Anaerobe. 2010 Dec;16(6):633-5. doi: 10.1016/j.anaerobe.2010.09.002. Epub 2010 Sep 16.
6
Antimicrobial resistance in Clostridium difficile.艰难梭菌的抗微生物药物耐药性。
Int J Antimicrob Agents. 2009 Dec;34(6):516-22. doi: 10.1016/j.ijantimicag.2009.09.012. Epub 2009 Oct 13.
7
Interplay in the selection of fluoroquinolone resistance and bacterial fitness.氟喹诺酮耐药性选择与细菌适应性之间的相互作用。
PLoS Pathog. 2009 Aug;5(8):e1000541. doi: 10.1371/journal.ppat.1000541. Epub 2009 Aug 7.
8
Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe.欧洲艰难梭菌感染前瞻性研究中艰难梭菌分离株对氟喹诺酮的耐药性
J Med Microbiol. 2008 Jun;57(Pt 6):784-789. doi: 10.1099/jmm.0.47738-0.
9
Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae.肺炎链球菌中氟喹诺酮耐药性的适合度代价
Antimicrob Agents Chemother. 2007 Feb;51(2):412-6. doi: 10.1128/AAC.01161-06. Epub 2006 Nov 20.
10
High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile.与毒素A阴性、毒素B阳性艰难梭菌gyrB基因新突变相关的对莫西沙星和加替沙星的高水平耐药性。
J Antimicrob Chemother. 2006 Dec;58(6):1264-7. doi: 10.1093/jac/dkl398. Epub 2006 Oct 3.

氟喹诺酮耐药性在体外对艰难梭菌的适应性没有造成代价。

Fluoroquinolone resistance does not impose a cost on the fitness of Clostridium difficile in vitro.

作者信息

Wasels François, Kuehne Sarah A, Cartman Stephen T, Spigaglia Patrizia, Barbanti Fabrizio, Minton Nigel P, Mastrantonio Paola

机构信息

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.

Clostridia Research Group, Centre for Biomolecular Sciences, School of Life Sciences, Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, The University of Nottingham, University Park, Nottingham, United Kingdom.

出版信息

Antimicrob Agents Chemother. 2015 Mar;59(3):1794-6. doi: 10.1128/AAC.04503-14. Epub 2014 Dec 22.

DOI:10.1128/AAC.04503-14
PMID:25534738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4325769/
Abstract

Point mutations conferring resistance to fluoroquinolones were introduced in the gyr genes of the reference strain Clostridium difficile 630. Only mutants with the substitution Thr-82→Ile in GyrA, which characterizes the hypervirulent epidemic clone III/027/NAP1, were resistant to all fluoroquinolones tested. The absence of a fitness cost in vitro for the most frequent mutations detected in resistant clinical isolates suggests that resistance will be maintained even in the absence of antibiotic pressure.

摘要

赋予对氟喹诺酮类药物耐药性的点突变被引入参考菌株艰难梭菌630的gyr基因中。只有在GyrA中发生苏氨酸-82→异亮氨酸取代的突变体对所有测试的氟喹诺酮类药物具有耐药性，这种取代是高毒力流行克隆III/027/NAP1的特征。在耐药临床分离株中检测到的最常见突变在体外不存在适应性代价，这表明即使在没有抗生素压力的情况下，耐药性也将得以维持。