Ahmadi Ali, Mobasheri Mahmoud, Hashemi-Nazari Seyed Saeed, Baradaran Azar, Choobini Zahra Molavi
Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Res Med Sci. 2014 Sep;19(9):850-4.
Type 2 diabetes mellitus (DM) and hypertension are worldwide epidemic. Association between DM and colon cancer was obtained in previous studies. Prevalence of DM and hypertension in the patients with colorectal cancer (CRC) has not been reported in Iran. The present study was aimed to investigate the prevalence of hypertension and type 2 DM and their effect on median survival time in patients with CRC.
Overall, 2570 individual-year follow-ups were conducted for 1127 patients with CRC. For the diagnosis of type 2 DM, fasting blood sugar test and glycosylated hemoglobin test were used and for hypertension, blood pressure was measured in two turns. The descriptive indices were calculated, and the mean and median survival from CRC diagnosis time was calculated using survival analysis and a comparison among survival times was done through log-rank test. Stata software 12 (Stata Corp. 2011. Stata Statistical Software: Release 12. College Station, TX: Stata Corp LP) was used for data analysis.
The prevalence of hypertension and type 2 DM in the patients with CRC was respectively 13.38% (95% confidence interval [CI]: 11.1-15.8) and 8.69% (95% CI: 7-10.7). Median survival time in patients with hypertension and DM were 8.52 and 4.9 years. According to log-rank test, no significant difference was observed between the survival time of CRC patients suffering from hypertension and diabetes type 2.
The obtained findings in this study indicate that survival time in patients with type 2 DM less than hypertension but two metabolic diseases have the same effect on survival rate of the patients with CRC. Understanding the risk factors for CRC may guide the development of strategies targeted toward its prevention.
2型糖尿病（DM）和高血压在全球范围内流行。先前的研究已证实DM与结肠癌之间存在关联。伊朗尚未报道过结直肠癌（CRC）患者中DM和高血压的患病率。本研究旨在调查高血压和2型DM的患病率及其对CRC患者中位生存时间的影响。
对1127例CRC患者进行了总计2570人年的随访。采用空腹血糖检测和糖化血红蛋白检测诊断2型DM，通过两次测量血压诊断高血压。计算描述性指标，使用生存分析计算CRC诊断时间后的平均生存时间和中位生存时间，并通过对数秩检验比较生存时间。使用Stata软件12（Stata公司，2011年。Stata统计软件：第12版。德克萨斯州大学站：Stata公司有限责任公司）进行数据分析。
CRC患者中高血压和2型DM的患病率分别为13.38%（95%置信区间[CI]：11.1 - 15.8）和8.69%（95%CI：7 - 10.7）。高血压和DM患者的中位生存时间分别为8.52年和4.9年。根据对数秩检验，患有高血压和2型糖尿病的CRC患者的生存时间之间未观察到显著差异。
本研究的结果表明，2型DM患者的生存时间短于高血压患者，但这两种代谢性疾病对CRC患者的生存率具有相同的影响。了解CRC的危险因素可能有助于制定针对性的预防策略。
