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关于使用同种异体骨块进行萎缩性上颌骨增量的可行性

On the feasibility of utilizing allogeneic bone blocks for atrophic maxillary augmentation.

作者信息

Monje Alberto, Pikos Michael A, Chan Hsun-Liang, Suarez Fernando, Gargallo-Albiol Jordi, Hernández-Alfaro Federico, Galindo-Moreno Pablo, Wang Hom-Lay

机构信息

Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Private practice, Palm Beach, FL, USA.

出版信息

Biomed Res Int. 2014;2014:814578. doi: 10.1155/2014/814578. Epub 2014 Sep 11.

Abstract

PURPOSE

This systematic review was aimed at assessing the feasibility by means of survival rate, histologic analysis, and causes of failure of allogeneic block grafts for augmenting the atrophic maxilla.

MATERIAL AND METHODS

A literature search was conducted by one reviewer in several databases. Articles were included in this systematic review if they were human clinical trials in which outcomes of allogeneic bone block grafts were studied by means of survival rate. In addition other factors were extracted in order to assess their influence upon graft failure.

RESULTS

Fifteen articles fulfilled the inclusion criteria and subsequently were analyzed in this systematic review. A total of 361 block grafts could be followed 4 to 9 months after the surgery, of which 9 (2.4%) failed within 1 month to 2 months after the surgery. Additionally, a weighed mean 4.79 mm (95% CI: 4.51-5.08) horizontal bone gain was computed from 119 grafted sites in 5 studies. Regarding implant cumulative survival rate, the weighed mean was 96.9% (95% CI: 92.8-98.7%), computed from 228 implants over a mean follow-up period of 23.9 months. Histologic analysis showed that allogeneic block grafts behave differently in the early stages of healing when compared to autogenous block grafts.

CONCLUSION

Atrophied maxillary reconstruction with allogeneic bone block grafts represents a reliable option as shown by low block graft failure rate, minimal resorption, and high implant survival rate.

摘要

目的

本系统评价旨在通过存活率、组织学分析以及同种异体块状移植骨用于上颌骨萎缩增量的失败原因来评估其可行性。

材料与方法

由一名研究者在多个数据库进行文献检索。如果文章是关于通过存活率研究同种异体骨块状移植骨结局的人体临床试验,则纳入本系统评价。此外,提取其他因素以评估其对移植骨失败的影响。

结果

15篇文章符合纳入标准,随后在本系统评价中进行分析。总共361块移植骨在术后4至9个月可进行随访,其中9块(2.4%)在术后1个月至2个月内失败。此外,在5项研究中的119个移植部位计算得出水平骨增量的加权平均值为4.79毫米(95%可信区间:4.51 - 5.08)。关于种植体累积存活率,在平均23.9个月的随访期内,从228颗种植体计算得出加权平均值为96.9%(95%可信区间:92.8 - 98.7%)。组织学分析表明,与自体块状移植骨相比,同种异体块状移植骨在愈合早期表现不同。

结论

同种异体骨块状移植骨用于萎缩上颌骨重建是一种可靠的选择(低移植骨失败率、最小吸收以及高种植体存活率)。

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