通过检测聚合免疫球蛋白A活性鉴别原发性与非原发性生殖器疱疹病毒感染
Differentiation of primary from nonprimary genital herpesvirus infections by detection of polymeric immunoglobulin A activity.
作者信息
Hashido M, Kawana T, Inouye S
机构信息
Department of Virology, University of Tokyo, Japan.
出版信息
J Clin Microbiol. 1989 Nov;27(11):2609-11. doi: 10.1128/jcm.27.11.2609-2611.1989.
Abstract
We analyzed antibody responses to herpes simplex virus (HSV) in 18 patients by using sucrose gradient centrifugation and an enzyme-linked immunosorbent assay for antibody determination. We found that the HSV-specific immunoglobulin A (IgA) antibody in early-convalescent-phase serum specimens from all of 8 primary cases consisted solely of polymeric forms, whereas in all 10 nonprimary cases, the major component was monomeric. These results indicate that the ratio of polymeric IgA to monomeric IgA antibody activity may be useful for differentiating primary from nonprimary HSV infections.
摘要
我们通过蔗糖梯度离心和酶联免疫吸附测定法检测抗体，分析了18例患者对单纯疱疹病毒（HSV）的抗体反应。我们发现，8例原发性病例的所有早期恢复期血清标本中的HSV特异性免疫球蛋白A（IgA）抗体均仅由聚合形式组成，而在所有10例非原发性病例中，主要成分是单体形式。这些结果表明，聚合IgA与单体IgA抗体活性的比率可能有助于区分原发性和非原发性HSV感染。
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