通过单纯疱疹病毒特异性免疫球蛋白G亲和力测定区分原发性与非原发性生殖器疱疹感染
Differentiation of primary from nonprimary genital herpes infections by a herpes simplex virus-specific immunoglobulin G avidity assay.
作者信息
Hashido M, Inouye S, Kawana T
机构信息
Department of Epidemiology, National Institute of Health, Shinjuku-ku, Tokyo, Japan.
出版信息
J Clin Microbiol. 1997 Jul;35(7):1766-8. doi: 10.1128/jcm.35.7.1766-1768.1997.
Abstract
An immunoglobulin G (IgG) antibody avidity assay which uses protein-denaturing agents and a modification of an enzyme-linked immunosorbent assay have been investigated for their usefulness in distinguishing primary genital herpes simplex virus (HSV) infections from nonprimary infections. Forty-nine serum specimens from patients with primary, recurrent, and nonprimary first-episode genital herpes were studied. The clearest separation was obtained with 6 M urea treatment, giving mean avidity indices of 0.398 for sera < or = 100 days after the infection and 0.879 for sera > 100 days after the infection (P < 0.001). No significant difference in avidity indices was observed between the recurrent and nonprimary first-episode infections. Determination of the avidity of HSV-specific IgG will improve the diagnostic potential of HSV serology.
摘要
一种使用蛋白质变性剂的免疫球蛋白G（IgG）抗体亲和力测定法以及酶联免疫吸附测定法的改良方法，已被研究其在区分原发性生殖器单纯疱疹病毒（HSV）感染与非原发性感染方面的实用性。对49例原发性、复发性和非原发性初发性生殖器疱疹患者的血清标本进行了研究。用6M尿素处理时得到了最清晰的区分，感染后≤100天的血清平均亲和力指数为0.398，感染后>100天的血清平均亲和力指数为0.879（P<0.001）。复发性感染和非原发性初发性感染之间的亲和力指数没有显著差异。测定HSV特异性IgG的亲和力将提高HSV血清学的诊断潜力。
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