Dong Li, Luo Cheng, Cao Weifang, Zhang Rui, Gong Jinnan, Gong Diankun, Yao Dezhong
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P.R. China.
Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu, P.R. China.
J Magn Reson Imaging. 2015 Sep;42(3):729-36. doi: 10.1002/jmri.24831. Epub 2014 Dec 24.
To characterize the local consistency by integrating temporal and spatial information in the local region using functional magnetic resonance imaging (fMRI).
One simulation was implemented to explain the definition of FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA). Then three experiments included resting state data (33 subjects), resting state reproducibility data (16 subjects), and event state data (motor execution task, 26 subjects) were designed. Finally, FOCA were respectively analyzed using statistical analysis methods, such as one-sample t-test and paired t-test, etc.
During resting state (Experiment 1), the FOCA values (P < 0.05, family-wise error [FWE] corrected, voxel size >621 mm(3) ) were found to be distinct at the bilateral inferior frontal gyrus, middle frontal gyrus, angular gyrus, and precuneus/cuneus. In Experiment 2 (reproducibility), a high degree of consistency within subjects (correlation ≈0.8) and between subjects (correlation ≈0.6) of FOCA were obtained. Comparing event with resting state in Experiment 3, enhanced FOCA (P < 0.05, FWE-corrected, voxel size >621 mm(3) ) was observed mainly in the precentral gyrus and lingual gyrus.
These findings suggest that FOCA has the potential to provide further information that will help to better understand brain function in neural imaging.
通过使用功能磁共振成像（fMRI）在局部区域整合时间和空间信息来表征局部一致性。
进行了一项模拟以解释局部神经活动的四维（时空）一致性（FOCA）的定义。然后设计了三个实验，包括静息态数据（33名受试者）、静息态可重复性数据（16名受试者）和事件态数据（运动执行任务，26名受试者）。最后，使用单样本t检验和配对t检验等统计分析方法分别分析FOCA。
在静息态期间（实验1），发现双侧额下回、额中回、角回和楔前叶/楔叶的FOCA值（P < 0.05，家族性错误率[FWE]校正，体素大小>621 mm(3)）明显不同。在实验2（可重复性）中，受试者内部（相关性≈0.8）和受试者之间（相关性≈0.6）的FOCA具有高度一致性。在实验3中比较事件态与静息态时，主要在中央前回和舌回观察到FOCA增强（P < 0.05，FWE校正，体素大小>621 mm(3)）。
这些发现表明，FOCA有可能提供进一步的信息，有助于在神经成像中更好地理解脑功能。
