Ma Shuai, Jiang Sisi, Peng Rui, Zhu Qiong, Sun Hongbin, Li Jianfu, Jia Xiaoyan, Goldberg Ilan, Yu Liang, Luo Cheng
Neurology Department, Sichuan Provincial People's Hospital, The Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Front Comput Neurosci. 2017 Sep 29;11:90. doi: 10.3389/fncom.2017.00090. eCollection 2017.
The purpose of this study was to evaluate the spatiotemporal Consistency of spontaneous activities in local brain regions in patients with generalized tonic-clonic seizures (GTCS). The resting-state fMRI data were acquired from nineteen patients with GTCS and twenty-two matched healthy subjects. FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) metric was used to analyze the spontaneous activity in whole brain. The FOCA difference between two groups were detected using a two sample -test analysis. Correlations between the FOCA values and features of seizures were analyzed. The findings of this study showed that patients had significantly increased FOCA in motor-related cortex regions, including bilateral supplementary motor area, paracentral lobule, precentral gyrus and left basal ganglia, as well as a substantial reduction of FOCA in regions of default mode network (DMN) and parietal lobe. In addition, several brain regions in DMN demonstrated more reduction with longer duration of epilepsy and later onset age, and the motor-related regions showed higher FOCA value in accompany with later onset age. These findings implicated the abnormality of motor-related cortical network in GTCS which were associated with the genesis and propagation of epileptiform activity. And the decreased FOCA in DMN might reflect the intrinsic disturbance of brain activity. Moreover, our study supported that the FOCA might be potential tool to investigate local brain spontaneous activity related with the epileptic activity, and to provide important insights into understanding the underlying pathophysiological mechanisms of GTCS.
本研究的目的是评估全身性强直阵挛发作（GTCS）患者局部脑区自发活动的时空一致性。静息态功能磁共振成像（fMRI）数据取自19例GTCS患者和22名匹配的健康受试者。采用局部神经活动的四维（时空）一致性（FOCA）指标分析全脑的自发活动。使用双样本t检验分析检测两组之间的FOCA差异。分析了FOCA值与癫痫发作特征之间的相关性。本研究结果表明，患者在与运动相关的皮质区域，包括双侧辅助运动区、中央旁小叶、中央前回和左侧基底神经节，FOCA显著增加，而在默认模式网络（DMN）和顶叶区域FOCA则大幅降低。此外，DMN中的几个脑区随着癫痫持续时间延长和发病年龄增大，FOCA降低更明显，而与运动相关的区域随着发病年龄增大，FOCA值更高。这些发现提示GTCS中与运动相关的皮质网络异常，这与癫痫样活动的发生和传播有关。DMN中FOCA降低可能反映了脑活动的内在紊乱。此外，我们的研究支持FOCA可能是研究与癫痫活动相关的局部脑自发活动的潜在工具，并为理解GTCS的潜在病理生理机制提供重要见解。
