van Zyl Gert U, Bedison Margaret A, van Rensburg Anita Janse, Laughton Barbara, Cotton Mark F, Mellors John W
Division of Medical Virology, Department Pathology, Stellenbosch University and National Health Laboratory Service, Tygerberg, South Africa.
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pennsylvania.
J Infect Dis. 2015 Jul 1;212(1):39-43. doi: 10.1093/infdis/jiu827. Epub 2014 Dec 23.
We measured cell-associated human immunodeficiency virus (HIV)-1 DNA (CAD) and RNA (CAR) and plasma HIV-1 RNA in blood samples from 20 children in the Children with HIV Early Antiretroviral (CHER) cohort after 7-8 years of suppressive combination antiretroviral therapy (cART). Children who initiated cART early (<2 months; n = 12) had lower HIV-1 CAD (median, 48 vs 216; P < .01) and CAR (median, 5 vs 436; P < .01) per million peripheral blood mononuclear cells than children who started later (≥ 2 months; n = 8). Plasma HIV-1 RNA levels were not significantly lower in early-treated children (0.5 vs 1.2 copies/mL; P = .16). Early treatment at <2 months of age reduces the number of HIV-infected cells and HIV CAR.
我们对接受抑制性联合抗逆转录病毒疗法（cART）7至8年的儿童早期抗逆转录病毒治疗（CHER）队列中的20名儿童的血样进行了细胞相关人类免疫缺陷病毒（HIV）-1 DNA（CAD）、RNA（CAR）及血浆HIV-1 RNA检测。与开始治疗较晚（≥2个月；n = 8）的儿童相比，早期开始cART（<2个月；n = 12）的儿童每百万外周血单个核细胞中的HIV-1 CAD（中位数，48对216；P <.01）和CAR（中位数，5对436；P <.01）更低。早期接受治疗的儿童血浆HIV-1 RNA水平并无显著降低（0.5对1.2拷贝/毫升；P = 0.16）。2个月龄前的早期治疗可减少HIV感染细胞数量及HIV CAR。
