Shabbal Dalili Mohammed, Jamda Mustapha Abubakar, Dalhatu Ibrahim Tijjani, Abdulrahman Muhammad Bashir, Isichei Chris
Department of Chemical Pathology, University of Abuja Teaching Hospital, Gwagwalada Federal Capital Territory, Nigeria.
Department of Community Medicine, University of Abuja Teaching Hospital, Gwagwalada Federal Capital Territory, Nigeria.
Niger Med J. 2014 Nov;55(6):508-11. doi: 10.4103/0300-1652.144711.
This study is to determine microalbuminuria in human immunodeficiency virus (HIV) infected patients before commencement of highly active anti-retroviral treatment (HAART).
Consecutive patients with the HIV infection seen in the HIV counselling and testing (HCT) unit of the Faith Alive Foundation Hospital, Jos, and a similar group of healthy uninfected patients were evaluated for renal disease: Urinary albumin and urinary creatinine were analysed.
Of the 200 patients with HIV infection and 100 uninfected controls studied, increased urinary albumin excretion (UAE) was present in 39 (19.5%) of the subjects and 5.0 (5.0%) of controls. The difference between the mean values for the UAE for both subjects and controls [182.3 ± 54.3 and 163.9 ± 39.3 mg/l, respectively (P = 0.006)] was statistically significant. On the other hand the urinary creatinine for both the subjects and controls [11.7 ± 5.2 and 12.0 ± 4.8 mmol/L, respectively (P = 0.6)] was not statistically significant. The difference between the mean urinary albumin/creatinine ratio (UACR) for both subjects and controls [1.8 ± 1.2 mg/mmol and 1.4 ± 0.4 mg/mmol respectively (P = 0.001)] was statistically significant.
CONCLUSION/RECOMMENDATION: Increase UAE is a common complication of HIV infection due to a number of factors other than HAART. Early screening for renal disease using microalbuminuria is very useful since the use of medications such as angiotensin converting enzyme inhibitors, which could help reverse progression to end-stage renal disease.
本研究旨在确定人类免疫缺陷病毒（HIV）感染患者在开始高效抗逆转录病毒治疗（HAART）之前的微量白蛋白尿情况。
对在乔斯市信仰生命基金会医院的HIV咨询与检测（HCT）科室就诊的连续HIV感染患者以及一组类似的未感染健康患者进行肾脏疾病评估：分析尿白蛋白和尿肌酐。
在研究的200例HIV感染患者和100例未感染对照中，39例（19.5%）受试者出现尿白蛋白排泄量（UAE）增加，而对照组为5例（5.0%）。受试者和对照组UAE的平均值之间的差异[分别为182.3±54.3和163.9±39.3mg/l，（P = 0.006）]具有统计学意义。另一方面，受试者和对照组的尿肌酐[分别为11.7±5.2和12.0±4.8mmol/L，（P = 0.6）]无统计学意义。受试者和对照组的平均尿白蛋白/肌酐比值（UACR）之间的差异[分别为1.8±1.2mg/mmol和1.4±0.4mg/mmol，（P = 0.001）]具有统计学意义。
结论/建议：除HAART外，多种因素导致UAE增加是HIV感染的常见并发症。使用微量白蛋白尿进行肾脏疾病的早期筛查非常有用，因为使用诸如血管紧张素转换酶抑制剂等药物有助于逆转至终末期肾病的进展。
