皮肤肿瘤促进抑制剂的研究。来自黄栌的三萜类化合物对爱泼斯坦-巴尔病毒激活的抑制作用。
Studies on inhibitors of skin-tumor promotion. Inhibitory effects of triterpenes from Cochlospermum tinctorium on Epstein-Barr virus activation.
作者信息
Diallo B, Vanhaelen M, Vanhaelen-Fastré R, Konoshima T, Kozuka M, Tokuda H
机构信息
Department of Pharmacognosy, U.L.B, Bruxelles, Belgium.
出版信息
J Nat Prod. 1989 Jul-Aug;52(4):879-81. doi: 10.1021/np50064a039.
PMID:2553872
Abstract
Arjunolic acid, an oleanene-type triterpene isolated from the rhizome of Cochlospermum tinctorium, its triacetate derivative, and their methyl esters were tested using the short-term in vitro assay on EBV-EA activation in Raji cells induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Their inhibitory effects on skin tumor promotors were found to be greater than those of previously studied natural products.
摘要
从黄栌根茎中分离得到的齐墩果烷型三萜阿朱诺酸、其三乙酸酯衍生物及其甲酯，采用短期体外试验，检测它们对12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的Raji细胞中EBV-EA激活的作用。发现它们对皮肤肿瘤促进剂的抑制作用比先前研究的天然产物更强。
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