Neuroscience Institute of the "Cavalieri Ottolenghi" Foundation (NICO) & Department of Clinical and Biological Sciences, University of Turin, Torino 10043, Italy.
Department of Traumatology, Microsurgery Unit, C.T.O. Hospital, Torino 10126, Italy.
Neural Regen Res. 2012 Oct 15;7(29):2267-72. doi: 10.3969/j.issn.1673-5374.2012.29.004.
It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that, to further improve clinical outcome, the involvement of different scientific disciplines is required. This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery, transplantation and biomaterials. In this paper, some of the most promising innovations for the tissue engineering of nerves, emerging from basic science investigation, are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation.
如今人们普遍认为，神经修复不仅仅是完美的显微重建问题，为了进一步提高临床效果，需要不同科学学科的参与。这种不断发展的修复/再生方法基于组织工程的跨学科和综合支柱，如修复显微外科、移植和生物材料。本文批判性地综述了基础科学研究中出现的一些最有前途的神经组织工程创新，特别关注那些目前似乎更适合临床转化的方法。
