College of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
Neural Regen Res. 2012 Oct 25;7(30):2370-6. doi: 10.3969/j.issn.1673-5374.2012.30.007.
Studies have shown that pre-moxibustion protects the gastric mucosa by up-regulating the expression of heat shock protein 70. However, the signaling pathway underlying this effect remains unclear. Rats were intragastrically administered absolute alcohol, causing obvious lesion of the gastric mucosa. Following pre-moxibustion at Zusanli (ST36) for 8 days, the ulcer index decreased to different degrees. The results of an enzyme linked immunosorbent assay and western blotting showed significant upregulation of heat shock protein 70 expression in the gastric mucosa and serum. None out of transection of the spinal cord, damage to the nucleus of the solitary tract, neurotomy of the vagal nerve and neurotomy of the common peroneal nerve affected the decrease in ulcer index or the increase in heat shock protein 70 expression in serum after pre-moxibustion at Zusanli, and heat shock protein 70 expression was obviously decreased in the gastric mucosa. These findings suggest that pre-moxibustion at Zusanli can protect the gastric mucosa against lesioning, and that the mechanism underlying this effect involves its induction of heat shock protein 70 expression. Neural pathways participate in the regulatory effects of moxibustion on heat shock protein 70 expression in the gastric mucosa.
研究表明，艾灸前处理通过上调热休克蛋白 70 的表达来保护胃黏膜。然而，这种作用的信号通路尚不清楚。大鼠给予胃内给予无水乙醇，导致胃黏膜明显损伤。艾灸足三里（ST36） 8 天后，溃疡指数有不同程度的下降。酶联免疫吸附试验和 Western blot 结果显示，胃黏膜和血清中热休克蛋白 70 的表达明显上调。脊髓横断、孤束核损伤、迷走神经切断和腓总神经切断均不影响艾灸足三里后溃疡指数的降低或血清中热休克蛋白 70 的增加，胃黏膜中热休克蛋白 70 的表达明显降低。这些发现表明，艾灸足三里可以保护胃黏膜免受损伤，这种作用的机制涉及诱导热休克蛋白 70 的表达。神经通路参与艾灸对胃黏膜热休克蛋白 70 表达的调节作用。
