Khatib Mahalaqua Nazli, Simkhada Padam, Gode Dilip
Department of Physiology, JNMC, Wardha, Maharashtra, India.
The School of Health and Related Research, The University of Sheffield, United Kingdom.
Heart Views. 2014 Jul;15(3):74-6. doi: 10.4103/1995-705X.144792.
Chronic heart failure (CHF) is a major cause of morbidity and mortality. Cardioprotective effects of ghrelin, especially in its acylated form have been demonstrated in heart failure (HF) models and exploratory human clinical studies. Hence, it has been proposed for the treatment of HF. However, the underlying mechanism of its protective effects against HF remains unclear. Future researches are needed to evaluate the efficacy of Ghrelin as a new biomarker and prognostic tool and for exploring its therapeutic potential in patients suffering from CHF.
慢性心力衰竭（CHF）是发病和死亡的主要原因。在心力衰竭（HF）模型和探索性人体临床研究中已证实了胃饥饿素的心脏保护作用，尤其是其酰化形式。因此，已有人提出将其用于治疗HF。然而，其对HF保护作用的潜在机制仍不清楚。需要未来的研究来评估胃饥饿素作为一种新的生物标志物和预后工具的有效性，以及探索其在CHF患者中的治疗潜力。
