京万红软膏治疗神经损伤性糖尿病足溃疡的疗效及其机制
The efficacy of Jing Wan Hong ointment for nerve injury diabetic foot ulcer and its mechanisms.
作者信息
Jin Shumei, Zhang Mixia, Gao Yan, Zhang Xuebin, Cui Guangzhi, Zhang Yanjun
机构信息
Tianjin Huanhu Hospital, Tianjin 300060, China.
Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, No. 312 Anshanxi Road, Nankai District, Tianjin 300193, China ; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China ; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
出版信息
J Diabetes Res. 2014;2014:259412. doi: 10.1155/2014/259412. Epub 2014 Nov 16.
Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.
京万红软膏含有30种中药，具有活血化瘀、清热利湿、解毒消肿的功效。因此，京万红软膏可能有助于溃疡愈合。本研究旨在评价京万红软膏对链脲佐菌素诱导及坐骨神经损伤所致Wistar大鼠糖尿病足溃疡的疗效及作用机制。结果表明，京万红软膏对初始神经损伤诱导的糖尿病大鼠足部溃疡有显著疗效。这些作用表现为治疗7天后足部溃疡大小减小和Wagner分级降低。足部溃疡的糖尿病大鼠在治疗21天后几乎愈合。此外，这种作用机制似乎依赖于PDGF mRNA表达的增加，但对TGF-β、VEGF和FLT-1 mRNA的表达没有影响。
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