迷迭香含水性提取物凝胶对链脲佐菌素诱导的糖尿病大鼠伤口愈合的影响。
The Effect of Myrtus communis Aqueous Extract-Containing Gel on Wound Healing in Streptozotocin-Induced Diabetic Rats.
机构信息
Department of Traditional Persian Medicine, Faculty of Medicine, Shahed University, Tehran, Iran.
Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran.
出版信息
Curr Drug Discov Technol. 2021;18(4):542-547. doi: 10.2174/1570163817666200712163956.
BACKGROUND
The medicinal plant Myrtus communis L. (Myrtle) has properties, including anti-inflammatory and wound healing in Persian Medicine.
OBJECTIVE
The objective of this study was to explore the wound healing potential of the local application of a gel containing aqueous extract of the plant berry in streptozotocin (STZ)-induced diabetic rats.
METHODS
Seven days after diabetes establishment, full-thickness excision skin wounds were made in normal and diabetic rats where treated groups received topical application of a gel containing 6% aqueous extract of myrtle berries for 3 weeks. The rate of wound healing and the level of epidermal and dermal maturation in the wound tissue were determined.
RESULTS
The results showed that after 3 and 7 days of wound injury, the gel significantly improved wound healing by accelerating epidermal and dermal maturation in diabetic rats with no significant effect in the control group. However, the wounds of all groups almost completely healed after 3 weeks.
CONCLUSION
These results demonstrate that aqueous extract of myrtle possesses a definite wound healing potential in diabetic conditions. The present findings may suggest the use of topical myrtle berries aqueous extract gel 6% to treat and manage intractable diabetic wounds.
背景
药用植物桃金娘（桃金娘）具有特性，包括在波斯医学中的抗炎和伤口愈合作用。
目的
本研究旨在探讨局部应用含有植物浆果水提取物的凝胶对链脲佐菌素（STZ）诱导的糖尿病大鼠伤口愈合潜力。
方法
在糖尿病建立后 7 天，在正常和糖尿病大鼠上进行全层切除皮肤伤口，其中治疗组接受含有 6％桃金娘浆果水提取物的凝胶的局部应用，持续 3 周。测定伤口愈合率和伤口组织中表皮和真皮成熟度的水平。
结果
结果表明，在伤口损伤后 3 天和 7 天，凝胶通过加速糖尿病大鼠表皮和真皮的成熟显著改善了伤口愈合，而在对照组中没有显著作用。然而，所有组的伤口在 3 周后几乎完全愈合。
结论
这些结果表明，桃金娘的水提取物在糖尿病情况下具有明确的伤口愈合潜力。本研究结果可能提示使用局部桃金娘浆果水提取物凝胶 6％来治疗和管理难治性糖尿病伤口。
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