Lilburn Timothy G, Cai Hong, Gu Jianying, Zhou Zhan, Wang Yufeng
328 Jamestown Road, Front Royal, VA 22630, USA.
Department of Biology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Int J Comput Biol Drug Des. 2014;7(4):369-83. doi: 10.1504/IJCBDD.2014.066554. Epub 2014 Dec 25.
The heat shock response is a general mechanism by which organisms deal with physical insults such as sudden changes in temperature, osmotic and oxidative stresses, and exposure to toxic substances. Plasmodium falciparum is exposed to drastic temperature changes as a part of its life cycle and maintains an extensive repertoire of heat shock response-related proteins. As these proteins serve to maintain the parasite in the face of anti-malarial drugs as well, better understanding of the heat shock-related systems in the malaria parasite will lead to therapeutic approaches that frustrate these systems, leading to more effective use of anti-malarials. Here we use protein association networks to broaden our understanding of the systems impacted by and/or implicated in the heat shock response.
热休克反应是生物体应对物理损伤的一种普遍机制，这些损伤包括温度突然变化、渗透和氧化应激以及接触有毒物质等。恶性疟原虫在其生命周期中会经历剧烈的温度变化，并拥有大量与热休克反应相关的蛋白质。由于这些蛋白质在疟原虫面对抗疟药物时也发挥着维持寄生虫生存的作用，因此更好地了解疟原虫中与热休克相关的系统将有助于开发破坏这些系统的治疗方法，从而更有效地使用抗疟药物。在这里，我们利用蛋白质关联网络来拓宽对受热休克反应影响和/或与之相关的系统的理解。
